Research Progress in Cancer Immunology: Tumor-derived Antigen Signals Induce CD8+ T-cell Exhaustion Localized to the Tumor Site Research Background and Purpose In recent years, immunotherapy has shown great potential in cancer treatment. However, tracking the behavior of immune cells after receiving antigen signals remains a challenge. Within tumor...

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...

Liver Danger Signal Triggers TREM2+ Macrophage-Mediated MS4A7-Dependent Inflammasome Activation Driving Steatohepatitis Background and Research Motivation In recent years, with the increasing incidence of metabolic dysfunction-associated steatohepatitis (MASH), its pathological mechanisms have garnered significant attention. MASH, formerly known as...

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells Academic Background Checkpoint inhibitors (CPIs) have revolutionized cancer treatment by blocking immune regulatory signals mediated by checkpoint molecules, restoring T cell-mediated tumor clearance. However, these therapies also lead to a range of immune-related adverse events (IRAEs), wi...

Research Report on the Analysis of Immunological Characteristics of Peripheral Blood in Cancer Patients Cancer is a major and pervasive health problem globally. Despite significant advances in cancer treatment in recent years, many challenges remain, including how to accurately predict patients’ responses to various treatments. Immunotherapy, parti...

Dendritic-cell-targeting Virus-like Particles as Potent mRNA Vaccine Carriers Introduction In vaccine development, especially mRNA vaccines, significant achievements have been made in recent years. The mRNA vaccines developed by Moderna and Pfizer/BioNTech against COVID-19 have set a successful precedent, greatly advancing the development of mRNA v...

Mesenchymal Stromal Cells with Chimeric Antigen Receptors for Enhanced Immunosuppression Background Mesenchymal Stromal Cells (MSCs) are pluripotent cells found in almost all tissues and possess significant immunosuppressive and regenerative properties. These features make MSCs widely studied for the treatment of immune diseases and tissue regenera...

Oncolytic Mineralized Bacteria May Be Used for Tumor Immunotherapy via Local Injection Research Background As a novel cancer treatment method, bacteria-based cancer immunotherapy has a long history dating back to the late 19th century when heated, inactivated bacteria were used to treat sarcomas. Initial trials found that these bacteria could trigg...

Physical Immunoevasion: Attenuated Mechanical Communication Facilitates Metastatic Colorectal Cancer Cells to Evade Macrophage Attack Background Introduction Cancer metastasis is a complex and daunting challenge, with metastatic cancer cells capable of evading immune cell attacks, breaching the extracellular matrix (ECM), and migrating to other sit...