Immunotherapy Efficacy Prediction for Non-Small Cell Lung Cancer Using Multi-View Adaptive Weighted Graph Convolutional Networks

Research Report on Immunotherapy Efficacy Prediction for Non-Small Cell Lung Cancer: A Study of Multi-View Adaptive Weighted Graph Convolutional Networks Background Introduction Lung cancer is a highly prevalent and poorly prognostic malignant tumor with a persistently high mortality rate. Among all lung cancer patients, Non-Small Cell Lung Cancer ...

Decreased Thalamocortical Connectivity in Resolved Rolandic Epilepsy

Decreased Thalamocortical Connectivity in Resolved Rolandic Epilepsy

Thalamocortical Connectivity Reduction in Rolandic Epilepsy Rolandic Epilepsy (RE), also known as self-limited epilepsy with centrotemporal spikes (SELECTS), is the most common localized developmental epileptic encephalopathy. This type of epilepsy is typically accompanied by transient mild to severe cognitive symptoms, sleep-related rolandic spike...

Salivary Testosterone Levels and Pain Perception Exhibit Sex-Specific Association in Healthy Adults but Not in Patients with Migraine

The Level of Salivary Testosterone and Pain Perception Show Sex-Specific Associations in Healthy Adults, But Not in Migraine Patients Introduction Understanding the complexity of pain and the role gender plays in pain perception is of significant importance in medical research. Pain is an unpleasant sensory and emotional experience associated with ...

Single-Subject Cortical Morphological Brain Networks: Phenotypic Associations and Neurobiological Substrates

This paper is a study on the phenotypic associations and neurobiological bases of single-subject morphological brain networks. Combining multimodal and multiscale data, this study reveals the differences in morphological brain networks between genders, their potential as individual-specific markers, and their relationships with gene expression, lay...

Histone 3 Lysine 9 Acetylation-Specific Reprogramming Regulates Esophageal Squamous Cell Carcinoma Progression and Metastasis

The Mechanism of Action of Specific Reprogramming of Histone H3 Lysine 9 Acetylation (H3K9ac) in the Progression and Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) Background Esophageal cancer is one of the most prevalent and invasive malignant tumors globally, causing over 500,000 cancer-related deaths annually, ranking sixth among cancer...

Modification of the Tumor Microenvironment Enhances Immunity with Plasmid Gene Therapy

The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...

Schwann cell derived pleiotrophin stimulates fibroblast proliferation and excessive collagen deposition in plexiform neurofibroma

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...

GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers

GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...

Retinoids and EZH2 Inhibitors Cooperate to Orchestrate Anti-Oncogenic Effects on Bladder Cancer Cells

Research Overview Recently, a paper published in the journal “Cancer Gene Therapy” titled “Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells” has garnered widespread attention among peers. This paper explores the combined application of retinoic acid and EZH2 inhibitors in bladder cancer cells and...

Enhanced Epithelial-Mesenchymal Transition Signatures Are Linked with Adverse Tumor Microenvironment, Angiogenesis, and Worse Survival in Gastric Cancer

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...