Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...
对于一篇关于血吸虫感染早期反应的深入研究，Houlder等人撰写的论文为科学界提供了重要的见解。他们的研究发表于《科学免疫学》(Sci. Immunol.) 2024年7月5日的第9卷，揭示了血吸虫（Schistosoma mansoni...
MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...
Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...
Review on the Study of IL-12 Promoting Human Follicular Regulatory T Cell Differentiation Research Background Follicular helper T cells (Tfh) play a crucial regulatory role in B cell responses to pathogens and vaccines. When not properly controlled, Tfh cells can lead to the production of antibodies against self-antigens or allergens. Follicular re...
Mini G Protein Inhibits Internalization of Same GPCR and Disrupts Downstream Intracellular Signaling Introduction G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, regulating cellular responses to external stimuli such as hormones and neurotransmitters. GPCRs transmit signals by coupling with guanine nucleotide-bi...
Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...
YAP Inhibits the TEAD-NF-κB Complex and Suppresses the Growth of Clear Cell Renal Cell Carcinoma Research Background Conventionally, the Hippo signaling pathway inhibits YAP-TEAD transcriptional complexes by keeping the transcriptional coactivator YAP phosphorylated and retained in the cytoplasm, thereby impeding tumor growth. However, researchers ...
In the context of today’s rapid advancement in science and technology, immunotherapy with natural killer (NK) cells has attracted widespread attention in the scientific community for their potential advantages in combating tumors and viral infections. Especially, the discovery of memory-like NK cells has brought new hope for NK cells as an anticanc...
Research on Network Construction and Application of Novel Drug Repositioning Strategies Background During the COVID-19 pandemic, researchers and pharmaceutical companies have been dedicated to developing treatments and vaccines. Drug repositioning, due to its shortcut, is considered a rapid and effective response strategy. Drug repositioning attemp...