The Mechanism of Action of Specific Reprogramming of Histone H3 Lysine 9 Acetylation (H3K9ac) in the Progression and Metastasis of Esophageal Squamous Cell Carcinoma (ESCC) Background Esophageal cancer is one of the most prevalent and invasive malignant tumors globally, causing over 500,000 cancer-related deaths annually, ranking sixth among cancer...

The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...

GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...

Research Overview Recently, a paper published in the journal “Cancer Gene Therapy” titled “Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells” has garnered widespread attention among peers. This paper explores the combined application of retinoic acid and EZH2 inhibitors in bladder cancer cells and...

Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...

LOXL1-AS1 Promotes Cholangiocarcinoma Progression by Regulating the JAK2/STAT3 Signaling Pathway Academic Background Cholangiocarcinoma (CCA) is a malignant tumor originating from biliary epithelium, presenting significant medical challenges. Its incidence shows geographical variation, being particularly high in Asia and South America. The occurren...

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...

Role of Syndecan Binding Protein (SDCBP) in Regulating Tumor Microenvironment, Tumor Progression, and Anti-PD1 Efficacy in Colorectal Cancer Background In recent years, immunotherapy has brought revolutionary advancements in cancer treatment. However, for colorectal cancer (CRC), anti-programmed cell death 1 (APD1) therapy shows relatively limited ...

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...