Central Nervous System (CNS) autoimmune diseases, such as Neuromyelitis Optica Spectrum Disorders (NMOSD), are inflammatory demyelinating conditions characterized by relapses of optic neuritis and myelitis. Despite significant progress in the treatment of NMOSD, a subset of patients responds poorly to current therapies, with recurrent and difficult...
Oxidative Phosphorylation Regulates B Cell Effector Cytokines and Promotes Inflammation in Multiple Sclerosis Background Introduction In recent years, the antibody-independent functions of B cells in health and disease have become a research hotspot, particularly their ability to secrete different cytokines that can activate or downregulate local i...
Nucleotide Base Adducts Bind MR1 and Stimulate MR1-Restricted T Cells Abstract This article provides an overview of the latest research by Vacchini et al. on MR1-restricted T cells (MR1T cells), which discovered the presence of nucleotide base adducts as MR1T cell antigens and unveiled their metabolic pathways and physiological functions in tumor c...
TREM2 Deficiency Remodels Intestinal Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy A research team from the Washington University School of Medicine, led by Blanda Di Luccia and other scientists, recently published a study in the journal Science Immunology, revealing how intestinal microbiota and tumor-associated macrophages i...
Immunoglobulin Superfamily Ligand B7H6 Enables T Cell Responses under NK Cell Surveillance Background In the field of immunology, understanding the mechanisms regulating T cell immunity is crucial for developing effective therapies for diseases related to T cell dysfunction, such as autoimmune diseases, chronic infections, and cancer. T cells media...
Major Breakthrough in Research for Autoimmune Neuroinflammation Treatment Background Introduction Steroid resistance is a significant challenge in the treatment of many inflammatory diseases, particularly autoimmune neuroinflammation. In these diseases, TH17 cells (T helper 17 cells) are widely regarded as key contributors to steroid resistance; ho...
Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...
The Effect of Nudcd3 Deficiency on V(D)J Recombination In the study of congenital immunodeficiency, especially in the field of T cell developmental abnormalities, identifying key genes and pathways is of great significance. Researches on Severe Combined Immunodeficiency (SCID) and Omenn Syndrome (OS) have highlighted the crucial roles of T cell rec...
Background Introduction The immune system plays a crucial role in responding to viral infections, and T cell memory is especially important in secondary immune responses. This paper focuses on how resident memory T cells (LN TRMs) in lymph nodes are formed after skin infections. LN TRMs play a key role in immune memory at specific sites, but their ...
Heart Failure Promotes Multimorbidity through Innate Immune Memory Background Introduction Heart failure (HF) is a common and fatal disease. Despite continuous advancements in medical technology, the mortality rate of heart failure remains high. HF patients frequently experience recurrent acute decompensation, which not only leads to the continuous...