Photocrosslinked Human Amniotic Membrane Hydrogel for Spinal Cord Injury Repair Academic Background Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to loss of motor function and a decline in the quality of life for patients. Despite significant advancements in tissue engineering and regenerative medicine in recent years,...
3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...
Study on Antimicrobial Gel Combined with Electrospun Polyvinyl Alcohol Fibers for Enzymatically Controlled Reactive Oxygen Species Release Academic Background The skin is the body’s first line of defense against infections, and the presence of wounds can compromise this barrier, increasing the risk of infection. With the rise of antibiotic resistan...
3D Bioprinted Cellulose/Collagen-Based Drug-Eluting Fillers for the Treatment of Deep Tunneling Wounds Academic Background Deep tunneling wounds are complex injuries that form beneath the skin surface, varying in shape and size, and may have twists and turns, making treatment extremely challenging. Current wound care solutions primarily target supe...
Light/pH Dual-Controlled Drug Release “Nanocontainer” Alleviates Tumor Hypoxia for Synergistic Enhanced Chemotherapy, Photodynamic Therapy, and Chemodynamic Therapy Academic Background In clinical cancer treatment, chemotherapy and radiotherapy have several limitations, such as drug resistance, incomplete treatment, and periodic recurrence. To over...
Application of 3D Printing Technology in Skeletal Muscle Vascularization Research Academic Background Skeletal muscle tissue is one of the most important tissues in the human body, and its function relies on the close relationship between myotubes and the vascular network. The vascular network not only supplies oxygen and nutrients to skeletal musc...
Novel Early Diagnosis Method for Lung Adenocarcinoma Based on DNA Methylation in Peripheral Blood Mononuclear Cells Background Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, accounting for approximately 40% of lung cancer cases. Despite significant advancements in treatment, the prognosis of LUAD remains...
Investigating the Validity of mCIM and sCIM Phenotypic Methods in Screening Pseudomonas aeruginosa Isolates Producing IMP, VIM, and NDM Metallo-β-Lactamases from Burn Wounds Background Pseudomonas aeruginosa is a Gram-negative bacterium widely found in the environment, particularly in hospital settings. It is the second most common pathogen causing...
Aztreonam-Avibactam Activity Against Multidrug-Resistant Klebsiella pneumoniae Complex Background The Klebsiella pneumoniae complex (KPC) is a group of opportunistic pathogens that pose a serious threat to public health. In recent years, the infection rate of multidrug-resistant (MDR) Klebsiella pneumoniae has significantly increased, leading to ex...
Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...