Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells in Patients with Checkpoint-Induced Colitis

Tracking In Situ Checkpoint Inhibitor-Bound Target T Cells Academic Background Checkpoint inhibitors (CPIs) have revolutionized cancer treatment by blocking immune regulatory signals mediated by checkpoint molecules, restoring T cell-mediated tumor clearance. However, these therapies also lead to a range of immune-related adverse events (IRAEs), wi...

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Hypoxic Macrophages in Glioblastoma with Therapeutic Potential for Vasculature Normalization

Identification of Therapeutic Potential of Hypoxic Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) and isocitrate dehydrogenase (IDH) mutant gliomas are the most common malignant brain tumors in adults. Tumor-associated macrophages (TAMs) are the major immune cell infiltrates in these tumors. These cells interact directly with ma...

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...

SMARCA4 is a Haploinsufficient B Cell Lymphoma Tumor Suppressor that Fine-Tunes Centrocyte Cell Fate Decisions

Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...

Mapping Functional to Morphological Variation Reveals the Basis of Regional Extracellular Matrix Subversion and Nerve Invasion in Pancreatic Cancer

The Biological Basis of Regional ECM Breakdown and Nerve Invasion in Pancreatic Cancer Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive types of cancer, typically associated with a highly fibrotic stroma, which can account for about 90% of the tumor mass. Although morphological heterogeneity is not addressed in routi...

Comprehensive Peripheral Blood Immunoprofiling Reveals Five Immunotypes with Immunotherapy Response Characteristics in Patients with Cancer

Research Report on the Analysis of Immunological Characteristics of Peripheral Blood in Cancer Patients Cancer is a major and pervasive health problem globally. Despite significant advances in cancer treatment in recent years, many challenges remain, including how to accurately predict patients’ responses to various treatments. Immunotherapy, parti...

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Pharmacogenomic Profiling of Intra-Tumor Heterogeneity Using a Large Organoid Biobank of Liver Cancer

Analysis of Intratumor Heterogeneity in Liver Cancer Using Pharmacogenomics: A Study Based on a Large-Scale Organoid Biobank Academic Background Primary liver cancer (PLC) is the third leading cause of cancer-related deaths worldwide, mainly comprising hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), and a mixed form called co...

Leptomeningeal Collaterals Regulate Reperfusion in Ischemic Stroke and Rescue the Brain from Futile Recanalization

Leptomeningeal Collaterals Regulate Reperfusion in Ischemic Stroke and Rescue the Brain from Futile Recanalization

Leptomeningeal Glial Modulation of Ischemic Stroke Reperfusion to Avoid Futile Recanalization Background Ischemic Stroke is caused by the sudden blockage of cerebral arteries, leading to millions of disabilities and deaths globally each year. The current treatment for ischemic stroke primarily involves intravenous thrombolysis or mechanical thrombe...

A Magnetic Particle Imaging Approach for Minimally Invasive Imaging and Sensing with Implantable Bioelectronic Circuits

Minimally Invasive Imaging and Sensing Methods Based on Magnetic Particle Imaging and the Application of Implanted Electronic Circuits Academic Background In modern medicine, minimally invasive and biocompatible implantable bioelectronics are widely used for long-term monitoring of physiological processes inside the body. However, methods for imagi...

Semi-Supervised Thyroid Nodule Detection in Ultrasound Videos

Semi-Supervised Thyroid Nodule Detection in Ultrasound Videos

Research Report on Semi-Supervised Detection of Thyroid Nodules in Ultrasound Videos Research Background Thyroid nodules are common thyroid diseases. Early screening and diagnosis of thyroid nodules typically rely on ultrasound examinations, a common non-invasive detection method used for detecting various diseases such as thyroid nodules, breast c...