Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Scientific Research Report Background Introduction For a long time, aging has been considered an irreversible process. However, recent research suggests that aging is a biological process that can be regulated. Various interventions have been shown to delay or even reverse certain characteristics of aging. Partial reprogramming is a method that rev...

Study on Human Muscle Aging Reveals Impact of Short-term Exercise on Lipid Composition Research Background As the global population ages, understanding the physiological changes associated with aging has become a key focus in scientific research. Previous studies using animal models have indicated that complex lipids, such as phospholipids, play im...

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...

Clinical Aging Clock Based on Principal Components Reveals Characteristics of Healthy Aging and Targets for Clinical Interventions Background of the Study As the population ages, promoting healthy aging and slowing down biological aging has become an important issue. To accurately predict all-cause mortality and obtain feasible measures to promote ...

Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...

Research on the Essence of Epigenetic Aging from a Single-Cell Perspective Research Background As biological research progresses, scientists have discovered that changes in DNA methylation (DNAm) constitute one of the most reliable predictors of age—known as the epigenetic clock. However, the mechanisms underlying what these clocks precisely measur...

Tumor Cell-Intrinsic PD-L1 Signaling Induces Epithelial-Mesenchymal Transition (EMT) Predicting Poor Response to Immune Checkpoint Inhibitors in PD-L1 High-Expressing Lung Cancer Research Background and Motivation In cancer immunotherapy, Programmed Death Ligand-1 (PD-L1) inhibits immune responses by binding to Programmed Death-1 (PD-1) receptors o...

Contribution of HMHA1/ARHGAP45 Expression Induced by Hypoxia and Post-Radiation Reoxygenation to Cancer Cell Invasion: An HIF-Dependent Mechanism Background and Motivation Prior studies have extensively demonstrated that cancer cells in solid tumors acquire malignant characteristics such as invasiveness and treatment resistance under hypoxic condit...

Study on the Key Role of Oncofetal snrpe in the Tumorigenesis and Progression of Hepatocellular Carcinoma Research Background and Purpose Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. However, due to the lack of understanding of key molecular events in tumors, effec...