The advent of single-cell RNA sequencing (scRNA-seq) technology has provided unprecedented resolution for studying gene expression dynamics during cell development and differentiation. However, due to the complexity of biological processes, cell developmental trajectories under different conditions are often asymmetric, posing challenges for data i...
Academic Background Drug-Target Interaction (DTI) prediction is a critical step in drug discovery, significantly reducing the cost and time of experimental screening. However, despite the advancements in deep learning that have improved the accuracy of DTI prediction, existing methods still face two major challenges: lack of generalizability and ne...
Academic Background Glioblastoma (GBM) is one of the most aggressive and heterogeneous central nervous system tumors, with an extremely poor prognosis. Despite the emergence of novel therapies such as anti-angiogenic treatments and immunotherapy in recent years, the survival period of GBM patients remains very limited. GBM cells exhibit unique meta...
Background Introduction Spinal Cord Injury (SCI) is a significant challenge in the medical field, particularly in terms of neural function recovery. Research indicates that neurons play a crucial role in spinal cord regeneration, but in complex pathological environments, neurons are influenced by various factors, leading to rapid senescence. Senesc...
Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...
High-precision Base Editing Technology in Primates and Human Retina Research Background Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. The protein encoded by the ABCA4 gene is a membrane lipid flippase localized i...
The Role of Major Cardiovascular Surgery-Induced Metabolic Reprogramming in Acute Kidney Injury: A Metabolomics Study Academic Background Cardiovascular diseases are the leading cause of death worldwide, accounting for over 17.9 million deaths annually, which is 32% of all deaths. As the disease burden increases, about one-third of patients may req...
S-nitrosylation of CRTC1 in Alzheimer’s Disease Impairs CREB-dependent Gene Expression Induced by Neuronal Activity Academic Background Alzheimer’s disease (AD) is a common neurodegenerative disorder characterized by the gradual loss of memory and cognitive function. The pathological mechanisms of AD are complex, involving various molecular and cel...
Radiation-Induced Cellular Plasticity Primes Glioblastoma for Forskolin-Mediated Differentiation Academic Background Glioblastoma (GBM) is one of the deadliest brain cancers in adults, with a median survival period of only 15 to 18 months for patients. Although surgery combined with chemoradiotherapy can delay disease progression, these treatments ...
Endocannabinoids Released on Demand via Extracellular Microvesicles Academic Background Endocannabinoids (ECBs) are a class of lipid neurotransmitters that play a critical role in brain function by activating cannabinoid receptor CB1. Unlike classical neurotransmitters, the storage and release mechanisms of ECBs have remained elusive, leading to si...