Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells

Background Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with a five-year survival rate of less than 20%, and treatment options are extremely limited. Traditional targeted drug therapies, such as Sorafenib and other kinase inhibitors, have been used to treat HCC, but their efficacy is limited and diffi...

Network-Wide Risk Convergence in Gene Co-Expression Identifies Reproducible Genetic Hubs of Schizophrenia Risk

The Genetic Network Aggregation Mechanism for Schizophrenia Risk — Latest Research Interpretation from the Journal “Neuron” In recent years, genetic research on schizophrenia (SCZ) has made significant progress, particularly driven by genome-wide association studies (GWAS), revealing a large number of genetic variants associated with the disease. H...

Failure in a Population: Tauopathy Disrupts Homeostatic Set-Points in Emergent Dynamics Despite Stability in the Constituent Neurons

Disturbance of Neuronal Homeostasis and Disruption of Neuronal Network Dynamics Caused by Tau Proteinopathy Background and Research Objectives Homeostatic mechanisms play a crucial role in maintaining the stability of brain functions. Under normal circumstances, neuronal activity set-points, such as firing rates, are dynamically adjusted through ho...

Integration and Competition Between Space and Time in the Hippocampus

A Review on the Mechanisms of Spatial and Temporal Integration and Competition in the Hippocampus Research Background and Significance In the human and animal brain, space and time comprise the primary dimensions of episodic memory, playing a crucial role in encoding information such as event sequences, locations, and durations. It has long been fo...

Phosphorylation of Piezo1 at a Single Residue, Serine-1612, Regulates Its Mechanosensitivity and In Vivo Mechanotransduction Function

This article is a biomedical research paper authored by scholars such as Zhang Tingxin, Bi Cheng, and Li Yiran, published on November 6, 2024, in the journal “Neuron.” The research was led by a team from the Tsinghua University-Peking University Center for Life Sciences, exploring the regulatory mechanism of phosphorylation modification of the mech...

A Neural Basis of Choking Under Pressure

The Neural Basis of Underperformance Under Pressure: An Analysis of the Interaction Between Reward Signals and Motor Preparation in Primate Brains Research Background “Choking under pressure” refers to situations where individuals fail to perform as expected due to the stress of important moments, as often seen with professional athletes during cri...

Synaptic Neoteny of Human Cortical Neurons Requires Species-Specific Balancing of SRGAP2-SYNGAP1

I. Research Background: Neoteny in Human Brain Development and Neurodevelopmental Disorders One of the remarkable features of human brain development is the slow developmental pace of cortical neurons. Compared to other mammals, especially non-human primates, the developmental process of human cortical neurons can last for several years. This neote...

A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

A Bimodal Taxonomy of Adult Human Brain Sulcal Morphology Related to Timing of Fetal Sulcation and Trans-Sulcal Gene Expression Gradients

Research Background and Objectives This study focuses on the complex morphological features of the adult cerebral cortex sulci, specifically the classification of linear and complex morphologies of brain sulci and their developmental mechanisms. The sulci are groove structures on the surface of the cerebral cortex, corresponding to different geneti...

Ferroptosis Triggered by Spliceosomal GTPase EFTUD2 Deficiency Leads to Purkinje Cell Degeneration

Depletion of EFTUD2 Triggers Ferroptosis-Induced Degeneration of Cerebellar Purkinje Cells Background and Motivation The cerebellum plays a crucial role in motor coordination and higher cognitive functions, with the health of cerebellar Purkinje cells (PCs) being essential for maintaining cerebellar function. Gene regulation based on alternative sp...

Disruption of Nuclear Speckle Integrity Dysregulates RNA Splicing in C9orf72-FTD/ALS

Disruption of Nucleolar Integrity and Dysregulation of RNA Splicing in C9orf72-FTD/ALS Background and Research Motivation The hexanucleotide repeat expansion (GGGGCC)n in the C9orf72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Studies have shown that these repeat sequences not only...