G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...
Academic Background In cell biology, focal adhesions (FAs) are key connection points between cells and the extracellular matrix (ECM), linking integrin receptors to the intracellular actin cytoskeleton. They play a crucial role in cell migration and polarization. Talin is a core protein in focal adhesions that directly connects integrin receptors t...
Study on Partially Unfolded Intermediate of γD-Crystallin Variants under Native Conditions Academic Background Human γD-crystallin is a structural protein in the eye lens, crucial for maintaining its transparency and stability. It must remain folded throughout an individual’s lifetime to avoid aggregation and protein deposition, thus preventing cat...
Research Background and Problem Statement Hereditary Folate Malabsorption (HFM) is a rare autosomal recessive disorder characterized by impaired intestinal absorption of folates and hindered transport across the choroid plexus into cerebrospinal fluid. This disease is caused by inactivating mutations in the gene encoding the Proton-Coupled Folate T...
A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...
Development and Validation of a Time-Varying Correction Factor for QT Interval Assessment in Drug-Resistant Tuberculosis Patients Academic Background and Research Motivation During the treatment of active tuberculosis (Tuberculosis, TB), patients often experience tachycardia (Tachycardia), which typically diminishes as they recover. Elevated heart ...
Promoting Healthy Longevity: Implementation Recommendations for the Hevolution Alliance for Aging Biomarkers Initiative Academic Background and Research Motivation With the intensification of global population aging, human life expectancy has significantly increased, but the growth in healthy life expectancy (i.e., years lived in good health) has b...
Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...
Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...
Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...