Reduced Graphene Oxide-Mediated Electron–Hole Separation Using Titanium Dioxide Increases the Photocatalytic Antibacterial Activity of Bone Scaffolds

Study on Reduced Graphene Oxide-Mediated Titanium Dioxide Photocatalytic Antibacterial Bone Scaffolds Academic Background Bacterial infection is one of the most common complications following the implantation of artificial bone scaffolds during bone defect repair. Bacteria form biofilms on the scaffold surface, releasing acids and enzymes that inte...

Research and Clinical Applications of Selective Laser Melting Tantalum Bone Plates

Research and Clinical Applications of Selective Laser Melted Tantalum Bone Plates Academic Background In the field of orthopedic implants, titanium (Ti)-based alloys and tantalum (Ta) are widely used due to their high biocompatibility. Titanium-based alloys are typically used to manufacture load-bearing implants, such as bone plates and femoral ste...

Enhancing Angiogenesis and Osseointegration through a Double Gyroid Ti6Al4V Scaffold with Triply Periodic Minimal Surface

Application of Double Gyroid Titanium Alloy Scaffolds Based on Triply Periodic Minimal Surface Structures in Bone Repair Academic Background Bone defect repair is a significant challenge in the field of orthopedics, especially in cases of critical-size bone defects caused by trauma, tumors, inflammation, and other diseases. Currently, the commonly ...

Magnesium and Gallium-Co-loaded Microspheres Accelerate Bone Repair via Osteogenesis and Antibiosis

Research on Magnesium and Gallium Co-loaded Microspheres Accelerating Bone Repair Academic Background Bone defects are a common clinical challenge, often caused by infection, tumor resection, or mechanical trauma. Bone defects not only affect patients’ quality of life but may also lead to functional loss. Although bone grafting is currently the pri...

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Cav3.3-Mediated Endochondral Ossification in a Three-Dimensional Bioprinted GelMA Hydrogel

Study on Cav3.3-Mediated Endochondral Ossification in 3D Bioprinted GelMA Hydrogel Research Background Bone development is a complex process, in which the growth plate (GP) plays a crucial role in the longitudinal growth of long bones. The growth plate regulates bone maturation through the process of endochondral ossification (EO). However, GP dysf...

Early-Life Malnutrition Exposure Associated with Higher Osteoporosis Risk in Adulthood: A Large-Scale Cross-Sectional Study

Early Malnutrition and the Risk of Osteoporosis in Adulthood: A Large-Scale Cross-Sectional Study Academic Background Osteoporosis is a chronic, systemic metabolic bone disease characterized by reduced bone density and deterioration of bone microstructure, leading to a significantly increased risk of fractures. Globally, approximately 9 million fra...

Adverse Complications of Cervical Spinal Fusion in Patients with Different Types of Diabetes Mellitus: A Retrospective Nationwide Inpatient Sample Database Cross-Sectional Study

Postoperative Complications of Cervical Spinal Fusion in Diabetic Patients: A Retrospective Study Background Diabetes Mellitus (DM) is a globally prevalent chronic condition that significantly impacts surgical outcomes, particularly in spine surgery. Diabetic patients face a higher risk of postoperative complications. However, over the past decade,...

RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination and Degradation of CBX7

RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination and Degradation of CBX7

RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination of CBX7 Academic Background Chondrosarcoma (CHS) is a malignant tumor composed of hyaline cartilage matrix and chondrocytes, ranking as the second most common primary bone tumor after osteosarcoma, accounting for 20%-27% of all primary malignant bone tumors. Although the 5-year s...

Advanced Bioresponsive Drug Delivery Systems for Promoting Diabetic Vascularized Bone Regeneration

Advanced Bioresponsive Drug Delivery Systems for Diabetic Vascularized Bone Regeneration Background The treatment of bone defects in patients with Diabetes Mellitus (DM) remains a significant challenge, as the diabetic microenvironment severely impedes bone regeneration. Various abnormal factors in the diabetic microenvironment, such as hyperglycem...

The SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction

SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...