Enhancing Immunomodulation and Osseointegration of Bone Implants: A Detailed Overview of Thrombin-Activated Platelet-Rich Plasma (PRP) Self-Assembly Technology Background Introduction To address the challenge of bone defect repair, bone implants play a critical role in modern medicine. However, existing bone implant materials like Polyetheretherket...

Research on 3D Bioprinted Scaffolds Promoting Bone Regeneration Academic Background In recent years, the incidence of head and craniofacial injuries has significantly increased due to the development of industries and transportation, as well as the frequent occurrence of wars and conflicts. These injuries and related treatments (such as decompressi...

Study on Reduced Graphene Oxide-Mediated Titanium Dioxide Photocatalytic Antibacterial Bone Scaffolds Academic Background Bacterial infection is one of the most common complications following the implantation of artificial bone scaffolds during bone defect repair. Bacteria form biofilms on the scaffold surface, releasing acids and enzymes that inte...

Research and Clinical Applications of Selective Laser Melted Tantalum Bone Plates Academic Background In the field of orthopedic implants, titanium (Ti)-based alloys and tantalum (Ta) are widely used due to their high biocompatibility. Titanium-based alloys are typically used to manufacture load-bearing implants, such as bone plates and femoral ste...

Application of Double Gyroid Titanium Alloy Scaffolds Based on Triply Periodic Minimal Surface Structures in Bone Repair Academic Background Bone defect repair is a significant challenge in the field of orthopedics, especially in cases of critical-size bone defects caused by trauma, tumors, inflammation, and other diseases. Currently, the commonly ...

Research on Magnesium and Gallium Co-loaded Microspheres Accelerating Bone Repair Academic Background Bone defects are a common clinical challenge, often caused by infection, tumor resection, or mechanical trauma. Bone defects not only affect patients’ quality of life but may also lead to functional loss. Although bone grafting is currently the pri...

Study on Cav3.3-Mediated Endochondral Ossification in 3D Bioprinted GelMA Hydrogel Research Background Bone development is a complex process, in which the growth plate (GP) plays a crucial role in the longitudinal growth of long bones. The growth plate regulates bone maturation through the process of endochondral ossification (EO). However, GP dysf...

Early Malnutrition and the Risk of Osteoporosis in Adulthood: A Large-Scale Cross-Sectional Study Academic Background Osteoporosis is a chronic, systemic metabolic bone disease characterized by reduced bone density and deterioration of bone microstructure, leading to a significantly increased risk of fractures. Globally, approximately 9 million fra...

Postoperative Complications of Cervical Spinal Fusion in Diabetic Patients: A Retrospective Study Background Diabetes Mellitus (DM) is a globally prevalent chronic condition that significantly impacts surgical outcomes, particularly in spine surgery. Diabetic patients face a higher risk of postoperative complications. However, over the past decade,...

RNF2 Promotes Chondrosarcoma Progression by Regulating Ubiquitination of CBX7 Academic Background Chondrosarcoma (CHS) is a malignant tumor composed of hyaline cartilage matrix and chondrocytes, ranking as the second most common primary bone tumor after osteosarcoma, accounting for 20%-27% of all primary malignant bone tumors. Although the 5-year s...