Physics-Informed Deep Learning for Musculoskeletal Modeling: Predicting Muscle Forces and Joint Kinematics from Surface EMG

Musculoskeletal models have been widely used in biomechanical analysis because they can estimate motion variables that are difficult to measure directly in living organisms, such as muscle forces and joint moments. Traditional physics-driven computational musculoskeletal models can explain the dynamic interactions between neural inputs to muscles, ...

Distribution of Coronal Plane Alignment of the Knee Classification in Chinese Osteoarthritic and Healthy Population: A Retrospective Cross-sectional Observational Study

A Retrospective Cross-Sectional Observational Study on the Distribution of Coronal Plane Alignment Classifications in Chinese Osteoarthritic and Healthy Populations Research Background Neutral mechanical alignment (MA) of the knee is considered the cornerstone of successful and durable total knee arthroplasty (TKA). However, the existence of “const...

Time of Exercise Differentially Impacts Bone Growth in Mice

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Three-Dimensional Postural Characteristics and Gender Differences in Human Shoulder Joint Stiffness Research Background The shoulder joint is one of the most complex joints in the human structure. Its stability is crucial for the effective control of arm movement, including the natural control of distal joints like the elbow and wrist, as well as f...

Estimation of Photon Path Length and Penetration Depth in Articular Cartilage Zonal Architecture Over the Therapeutic Window

Academic News Report: Study on the Optical Transmission Characteristics of Cartilage Introduction Cartilage is a complex biological tissue composed of cells and a substantial extracellular matrix. Its main components include collagen fibers, proteoglycans, and water, which form layered structural partitions at the microscopic level. The propagation...

Patterns of Sagittal Imbalance in Degenerative Kyphosis and Its Implication on Postoperative Mechanical Failure

Patterns of Sagittal Imbalance in Degenerative Kyphosis and Its Implication on Postoperative Mechanical Failure

Sagittal Imbalance Patterns in Degenerative Kyphosis of the Lumbar or Thoracolumbar Spine and Their Impact on Postoperative Complications Research Background Degenerative kyphosis (DK) is the most common type of spinal deformity in the elderly. Sagittal imbalance is a typical radiological feature of DK and is associated with a severe decline in qua...

Caudal Agenesis: Classification Based on the Pathoembryogenesis of the Spinal Cord

This is a report on a new classification method for caudal agenesis: Caudal agenesis is a congenital disorder characterized by the absence of lower vertebrae. Previous classifications of caudal agenesis were primarily based on the level of bony deficiency or the position of the terminal spinal cord, but there has been debate as to whether these cla...

Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy

Sarcoma microenvironment cell states and ecosystems are associated with prognosis and predict response to immunotherapy

This study utilized a machine learning framework to explore the underlying cell states and cellular ecosystems constituting soft tissue sarcomas, and associated them with patient prognosis and response to immunotherapy. Research Background: Soft tissue sarcomas are rare and highly heterogeneous malignancies of connective tissues, with limited syste...