The Role of Sirtuins in Obesity and Osteoporosis and Their Therapeutic Potential Academic Background Obesity and osteoporosis (OP) are increasingly severe public health issues worldwide. Obesity is not only closely related to metabolic diseases such as cardiovascular diseases and diabetes but also has a complex association with the occurrence of os...

Novel Germline Mutations in FUT7 and EXT1 Linked to Hereditary Multiple Exostoses Background Hereditary Multiple Exostoses (HME), also known as Hereditary Multiple Osteochondromas (HMO), is an autosomal dominant skeletal disorder characterized by the development of multiple cartilage-capped bone projections (osteochondromas). These osteochondromas ...

Academic Research Report: MCL1 Copy Number Gain as a Therapeutic Target for Osteosarcoma Academic Background Osteosarcoma (OS) is a primary malignant bone tumor that predominantly affects children and adolescents. Although the treatment regimen combining surgery with chemotherapy was established in the 1970s and remains the standard therapy, progre...

Osteochondral Abnormalities on Three-Dimensional Ultrashort Echo Time MRI Scans Are Associated with Knee Cartilage Degradation Academic Background Osteoarthritis (OA) is the most prevalent musculoskeletal disease, characterized by pain and disability. A hallmark of OA is the progressive loss of articular hyaline cartilage, which connects to the sub...

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....

Automated Clinical Assessment of Abnormal Walking Movements in ABI Patients Through Image Extraction and Classification Systems Academic Background Walking disability is a common physical impairment following Acquired Brain Injury (ABI). ABI typically includes stroke and traumatic brain injury, with a global incidence of approximately 1.5 million c...

Safety and Efficacy: The Impact of Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation Background Stroke is the leading cause of disability among adults in the United States, with up to 80% of stroke survivors experiencing gait impairments, such as reduced walking speed, endurance, and asymmetrical gait, thereby limiting their ability to wa...

The Impact of Exoskeleton Rehabilitation Robot Training on Balance and Lower Limb Function in Subacute Stroke Patients: A Preliminary, Randomized Controlled Trial Research Background and Purpose Stroke is a leading cause of death and disability worldwide. With the rapid development of stroke treatment technology, the mortality rate of stroke has si...

Study on the Differential Effects of Blood Flow Restriction Training on Strength Gains and Precise Force Control Research Background Blood Flow Restriction (BFR) training, an emerging method for enhancing muscle strength, has garnered attention from researchers and clinical medicine in recent years. BFR training with low-load resistance exercise en...

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...