Application of the Deep Reconstruction Framework with Self-Calibration Mechanisms (DEISM) in Accelerated Chemical Exchange Saturation Transfer Imaging Academic Background Chemical Exchange Saturation Transfer (CEST) imaging is a highly sensitive molecular magnetic resonance imaging technique capable of detecting biomolecules associated with various...
Machine Learning Study on the Relationship Between Heart Rate and Body Temperature in Pediatric Intensive Care Units Academic Background In the pediatric intensive care unit (PICU), heart rate (HR) and body temperature (BT) are crucial clinical indicators that reflect a patient’s physiological status. Although the relationship between HR and BT has...
Research on Real-Time 3D Reconstruction and Navigation in Neuroendoscopy Based on Self-Supervised Learning Academic Background Neuroendoscopic surgery, as a minimally invasive surgical technique, is widely used in the treatment of deep brain lesions, such as endoscopic third ventriculostomy (ETV), choroid plexus cauterization, and cyst fenestration...
Research Report: The Role of Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances Academic Background For a long time, carbohydrate (CHO) intake has been considered a key factor in enhancing athletic performance during endurance exercise. The traditional view holds that a high-carbohydrate low-fat diet (HCLF) can increase ...
The Impact of Estrogen Deficiency on Vascularization and Mineralization Dynamics—Insights from a Novel 3D Humanized and Vascularized Bone Organoid Model Academic Background Osteoporosis is a common bone disease, particularly prevalent among postmenopausal women. Osteoporosis not only manifests as a reduction in bone mass but also involves changes i...
CDC42 Plays a Crucial Role in the Early Regulation of Hepatic Stellate Cell Activation Academic Background Liver fibrosis is a pathological process associated with various liver diseases, which may eventually progress to cirrhosis—a life-threatening condition. Currently, there are no effective treatments to halt the progression of liver fibrosis. H...
NAD+ Protects Hepatocytes Against Palmitate-Induced Lipotoxicity by Preventing PARP-1 Inhibition and mTORC1-p300 Pathway Activation Research Background Metabolic dysfunction-associated fatty liver disease (MAFLD) encompasses a spectrum of liver diseases ranging from simple steatosis to steatohepatitis, fibrosis/cirrhosis, and even hepatocellular ca...
O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-DOPA Levels Research Background In the nervous system, dopamine is a key neurotransmitter, and the rate-limiting enzyme in its synthesis pathway is tyrosine hydroxylase (TH). The activity of TH is regulated by various post-translational modifications (PTMs), among which ...
Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...
Modeling of Ion and Water Transport on the Human Ocular Surface Background Introduction The ocular surface plays a crucial role in human physiology and diseases, especially the stability and composition of the tear film, which directly impact ocular surface health. The tear film consists of three layers: an outer lipid layer (secreted by the meibom...