Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...
Romidepsin Exhibits Anti-Esophageal Squamous Cell Carcinoma Activity through DDIT4-mTORC1 Pathway Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies globally, with high incidence and mortality rates. Given the limited current treatment options, there is an urgent need to develop new effective therapeutic drugs. I...
Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...
AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...
Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...
Precise and Safe Lung Segmentectomy Enabled by Dual-Channel Near-Infrared Fluorescence Tumor and Pleural Demarcation Lung cancer is a leading cause of cancer-related deaths globally. Since the introduction of computed tomography screening, the early detection rate of lung cancer has greatly increased, significantly reducing mortality rates. Studies...
The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...
Study on Metabolic Differences between IDH Mutant and Wild-type Glioma Cells Using Raman Spectroscopy and Machine Learning Platform Background Introduction In the diagnosis and treatment of gliomas, formalin-fixed, paraffin-embedded (FFPE) tissue sections are commonly used. However, due to background noise interference from the embedding medium, th...
Manifestations of Genomic-Level Intratumoral Tumor Heterogeneity in Multi-Region Patient-Derived Xenograft Models of Non-Small Cell Lung Cancer Academic Background and Research Motivation Patient-Derived Xenograft (PDX) models are widely used in cancer research. PDX models are established by transplanting human tumors into immunodeficient mice. The...
Systematic Analysis of NDUFAF6 in Complex I Assembly and Mitochondrial Disease Background Mitochondrial complex I (CI) is a crucial component of the respiratory chain, playing an essential role in oxidative phosphorylation (OXPHOS) by introducing electrons into the mitochondrial respiratory chain and, together with complexes II-IV, generating and m...