Research Report on Efferocytosis Features and Their Prognostic and Immunotherapy Associations in Lung Adenocarcinoma Background and Research Motivation Lung cancer is a leading cause of cancer-related mortality worldwide, with lung adenocarcinoma (LUAD) being the most common histological subtype. Due to the insidious nature of the disease and lack ...
Tumor Analysis of BRCA1/2 Carriers: Genomic Similarities Evident Across Different Time Points Breast cancer (BC) is the most common malignant tumor among women globally, with its pathogenesis predominantly sporadic, while familial hereditary cases account for only 5% to 10%. Among various pathogenic molecules, mutations in the BRCA1/2 genes (Pathog...
The Impact of Radioresistant-Related Telomere Genes on Prognosis and Immune Infiltration in Lung Adenocarcinoma Lung adenocarcinoma (LUAD), a common subtype of non-small cell lung cancer (NSCLC), has a high incidence and mortality rate. Despite significant progress in early detection and treatment, the overall survival (OS) rate of LUAD patients re...
Long-term Intravenous Anti-CD20 Antibody Therapy Assessment in a French Multiple Sclerosis Cohort Background and Research Motivation Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system, leading to varying degrees of physical and cognitive impairment. Recent Phase II and III clinical trials of...
Optimized Nutritional Interventions Improve Muscle Fatigue, Strength, and Quality of Life in Patients with Primary Mitochondrial Disease Background Introduction Primary mitochondrial disease (PMD) encompasses a group of disorders caused by mutations in mitochondrial DNA or nuclear DNA, affecting systemic energy metabolism. The prevalence is approxi...
Overview of Nitroglycerin-Based Neuroprotection in Acute Ischemic Stroke: A Pilot Randomized Controlled Trial Review Background and Research Objectives Acute ischemic stroke (AIS) is one of the leading global causes of disability and death. Despite the significant improvement in vascular recanalization rates and patient outcomes achieved with moder...
Research Report: Reshaping Functional Hierarchies in Medication-Refractory Essential Tremor Through MRgFUS Therapy Essential tremor (ET), a prevalent movement disorder, is characterized by involuntary limb tremors, particularly noticeable during specific tasks. While traditional pharmacological treatments and deep brain stimulation (DBS) have shown...
Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...
Background and Research Motivation Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons, leading to progressive muscle paralysis and eventual death. Currently, no effective treatments can significantly delay or halt ALS progression. While various ALS mouse models (such as those carry...
Research Report on the Improvement of CMT-like Neuropathy via AAV9 Vector-based C1ORF194 Gene Therapy Background and Research Motivation Charcot-Marie-Tooth disease (CMT) is a rare group of genetically heterogeneous neuromuscular disorders characterized by progressive muscle weakness and atrophy, along with sensory loss. Despite extensive preclinic...