Aging-Induced MCPH1 Translocation Activates Necroptosis and Impairs Hematopoietic Stem Cell Function

Study on MCPH1 Nuclear Transfer Induced by Aging Activating Necrosis and Impairing Hematopoietic Stem Cell Function Research Background The aging of hematopoietic stem cells is associated with an increased risk of various blood diseases, and DNA damage is a significant factor driving the aging of hematopoietic stem cells. However, the underlying mo...

Targeting Dysregulated Phago-/Auto-Lysosomes in Sertoli Cells to Ameliorate Late-Onset Hypogonadism

Research Background This study focuses on late-onset hypogonadism (LOH), aiming to uncover the mechanisms associated with age-related testicular function deviations, such as LOH, which are not yet fully understood. Utilizing single-cell RNA sequencing technology, the study analyzed the testicles of humans with LOH to identify supporting cells (SCs)...

Estrogen Counteracts Age-Related Decline in Beige Adipogenesis Through the NAMPT-Regulated ER Stress Response

Reversal of Beige Fat Decline by Estrogen Through NAMPT-Regulated Endoplasmic Reticulum Stress Response Abstract: Brown adipocytes are valued for their potential therapeutic effects against metabolic diseases. However, the metabolic advantages provided by these cells deteriorate with age. Our research shows that treating mice with estrogen (E2), a ...

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

A Single-Nuclei Paired Multiomic Analysis of the Human Midbrain Reveals Age- and Parkinson’s Disease–Associated Glial Changes

Single-nucleus Multi-omics Analysis Reveals Age-related and Parkinson’s Disease-related Changes in Neuroglia in the Human Midbrain Research Background Age is a major risk factor for Parkinson’s Disease (PD). Although the significant role of age in PD onset is known, details about how age alters the gene expression and regulatory landscape of the br...

Single-Nucleus Sequencing Reveals Enriched Expression of Genetic Risk Factors in ALS-Sensitive Neurons

Publication of a New Study on ALS Neurodegeneration in 《Nature Aging》 Throughout human history, numerous mysterious diseases have posed significant challenges for scientific research. Among these, Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease, is known for the gradual loss of muscle function and disability it causes. ...

Restoration of Neuronal Progenitors by Partial Reprogramming in the Aged Neurogenic Niche

Scientific Research Report Background Introduction For a long time, aging has been considered an irreversible process. However, recent research suggests that aging is a biological process that can be regulated. Various interventions have been shown to delay or even reverse certain characteristics of aging. Partial reprogramming is a method that rev...

Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

Small Extracellular Vesicles in Young Plasma Reverse Age-Related Functional Decline by Improving Mitochondrial Energy Metabolism Background In recent years, research on heterochronic parabiosis has revealed significant regenerative effects of young blood on elderly tissues. However, the specific regenerative mechanisms are not fully understood. Thi...

A Conserved Complex Lipid Signature Marks Human Muscle Aging and Responds to Short-Term Exercise

Study on Human Muscle Aging Reveals Impact of Short-term Exercise on Lipid Composition Research Background As the global population ages, understanding the physiological changes associated with aging has become a key focus in scientific research. Previous studies using animal models have indicated that complex lipids, such as phospholipids, play im...

Spatiotemporal Transcriptomic Changes of Human Ovarian Aging and the Regulatory Role of FOXP1

Research Report on Spatiotemporal Transcriptomic Changes in Human Ovarian Aging and the Regulatory Role of FOXP1 Academic Background With the continuous increase in global average life expectancy, health issues faced by women during menopause are receiving increasing attention. Ovarian aging is one of the significant issues, closely related to vari...

Age-dependent Loss of Hapln1 Erodes Vascular Integrity via Indirect Upregulation of Endothelial ICAM1 in Melanoma

Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma In a research article titled “Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma” published in Nature Aging in March 2024, significant findings have been revealed. The study...