Study Reveals Molecular Mechanisms of Enhanced Cocaine Craving in Rats During Withdrawal Background Introduction The issue of relapse in drug abuse poses a significant challenge in addiction treatment. According to related research, relapse behaviors in drug addiction are often triggered by environmental cues associated with drug use. This phenomen...

New Findings in Alzheimer’s Disease Research: The Regulatory Role of Signal Peptide Peptidase-Like 2b in the β-Amyloid Cascade Alzheimer’s Disease (AD) is a complex neurodegenerative disorder characterized by the abnormal accumulation of β-amyloid peptides (Aβ) in brain tissue and the formation of intracellular neurofibrillary tangles. The abnormal...

APP/PS1 Mouse Study Reveals Link Between Chronic Induced Epilepsy and Alzheimer’s Disease Background Alzheimer’s Disease (AD) is the most common type of dementia globally, affecting over 55 million people. The typical pathological feature of AD is the deposition of amyloid-β (Aβ) in the brain. Although Aβ deposition and the mechanisms it triggers p...

Research Report on Mixed Selectivity in Monkey Anterior Intraparietal Area During Visual and Motor Processes Background In recent years, the anterior intraparietal area (AIP) has garnered significant interest in the field of neuroscience. AIP is considered a convergence node for multiple visual and somatosensory information, including the physical ...

Analysis of the Effect of Central LEAP-2 on Food Intake and Its Impact on Nucleus Accumbens Dopamine Release Background Introduction Gut-brain peptides such as ghrelin and their receptors have been established as important factors in regulating hunger and reward processing. However, the liver-expressed antimicrobial peptide 2 (Leap2), an inverse ag...

Reducing Fibroblast Activation and Fibrosis in Systemic Sclerosis through Adropin Fibrotic diseases of the skin and other organs have become significant socioeconomic challenges in modern society, and current treatment options are limited. This background for this study seeks to address the problem of fibrosis in Systemic Sclerosis (SSc), with the ...

This article is written by Jeremy M. Sullivan et al. and published in the journal “Science Translational Medicine” on May 22, 2024, titled “Gain-of-function TRPV4 Mutations in Endothelial Cells Disrupt the Blood-Spinal Cord Barrier and Cause Motor Neuron Degeneration in Mice.” Academic Background The research background of this article revolves aro...

Using the Suppression of Cytoplasmic Iron-Sulfur Cluster Assembly to Restore PTEN and Inhibit Glioma Stem Cells Background Glioblastoma (GBM) is one of the most lethal primary brain tumors. Glioma stem cells (GSCs) not only initiate and sustain the malignant phenotype but also enhance treatment resistance. Although PTEN frequently mutates in gliobl...

Scientists Reveal the Anti-Tumor Mechanism of Src Inhibitors in IDH Mutant Cholangiocarcinoma Background Introduction In recent years, the incidence of intrahepatic cholangiocarcinoma (ICC) has been rising worldwide. ICC is a highly invasive tumor usually lacking noticeable symptoms in the early stages, with cases often being inoperable by the time...

Background Gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, regulating neuronal activity and plasticity through two distinct modes: phasic and tonic. However, our understanding of the mechanisms and physiological functions of GABA transmission in glial cells remains limited. Glial cells, especially astrocytes, ca...