Plasma Membrane Damage Limits Replicative Lifespan in Yeast and Induces Premature Senescence in Human Fibroblasts

Scientific Research Report: Plasma Membrane Damage Limits Yeast Replicative Lifespan and Induces Premature Senescence in Human Fibroblasts Background and Research Motivation Plasma Membrane Damage (PMD) is a phenomenon experienced by all cell types in response to environmental disturbances and spontaneous cellular activities. Previous studies have ...

HLA-A+ Tertiary Lymphoid Structures with Reactivated Tumor-Infiltrating Lymphocytes Are Associated with a Positive Immunotherapy Response in Esophageal Squamous Cell Carcinoma

In esophageal squamous cell carcinoma (ESCC), immune checkpoint blockade (ICB) therapy has achieved significant clinical benefits. However, the overall response rate to ICB treatment remains low. This study aims to identify biomarkers for ESCC response to ICB therapy and explore their potential clinical relevance. The authors of the paper come from...

Epigenetic Activation of SOX11 is Associated with Recurrence and Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Comprehensive Genomic and Transcriptomic Characterization of High-Grade Gastro-Entero-Pancreatic Neoplasms

Research Report on Comprehensive Genomic and Transcriptomic Characteristics of High-Grade Gastro-Entero-Pancreatic Neuroendocrine Tumors Research Background High-grade gastro-entero-pancreatic neuroendocrine neoplasms (HG GEP-NENs) are a heterogeneous group of malignant tumors characterized by neuroendocrine differentiation. According to WHO 2019 [...

Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth through Stabilizing BRD2

The research results, completed in collaboration by many scientists including Lishu Chen, Qinghui Qi, and Xiaoqing Jiang, were published in the groundbreaking journal Cancer Discovery. The report detailed how phosphocreatine (PCr) promotes the growth of glioblastoma (GBM) by stabilizing bromodomain-containing protein 2 (BRD2). This discovery provid...

CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma

Research Report on the Regulation of Neuron-Glioma Interactions by CHD2 in Pediatric Gliomas Background High-grade gliomas (HGG) are fatal diseases in both adult and pediatric patients. Recent studies have shown that neuronal activity can promote the progression of various high-grade glioma subgroups. However, the epigenetic mechanisms regulating t...

St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors

St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors

St. Jude Survivorship Portal: Analysis and Sharing of Large-Scale Clinical and Genomic Data of Pediatric Cancer Survivors Research Background In the United States, the five-year survival rate for childhood cancer has increased from about 60% in the 1970s to over 85% today. Despite the significant improvement in survival rates, these childhood cance...

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

In the current field of tumor treatment, precision medicine continues to be a research hotspot and development trend. With the advancement of science and technology, we have begun to more accurately understand the characteristics of tumor cells and their dependencies for survival, in hopes of finding new therapeutic targets. Particularly, strategie...

ror2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

ror2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

Research Report: The Regulatory Role of ROR2 in Pancreatic Cancer Cell Plasticity Background Introduction Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with most patients lacking the possibility of a cure. This is partly due to the difficulty in early detection. One of the characteristics of PDAC is its extensive tumor cell heterogene...

Oncogenic KRAS-dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth

The Role of IL-33 in Promoting Tumor Growth in Pancreatic Cancer Tissue and its Potential as a Therapeutic Target Background Introduction Pancreatic Cancer (PDA) is one of the most lethal malignancies worldwide, characterized by rapid clinical progression and poor treatment responses, with a five-year survival rate of only 13%. In the United States...