Academic News Report: The Temporal and Spatial Bias in β-arrestin Signal Transduction Mediated by G Protein-Coupled Receptor Endocytosis Research Background Among cell surface receptor families, G protein-coupled receptors (GPCRs) constitute the largest family. Upon activation by ligands, they interact with various signaling proteins to trigger int...
Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...
Mini G Protein Inhibits Internalization of Same GPCR and Disrupts Downstream Intracellular Signaling Introduction G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, regulating cellular responses to external stimuli such as hormones and neurotransmitters. GPCRs transmit signals by coupling with guanine nucleotide-bi...
In the context of today’s rapid advancement in science and technology, immunotherapy with natural killer (NK) cells has attracted widespread attention in the scientific community for their potential advantages in combating tumors and viral infections. Especially, the discovery of memory-like NK cells has brought new hope for NK cells as an anticanc...
The Ventral Subiculum Promotes Wakefulness Through Multiple Pathways in Male Mice Background The ventral subiculum (vsub) is a major output region of the hippocampus, playing a crucial role in motivation, stress integration, and anxiety-like behavior, all of which depend on a high state of wakefulness. However, the role of vsub in wakefulness and i...
Overview A paper titled “Supervised latent factor modeling isolates cell-type-specific transcriptomic modules that underlie Alzheimer’s disease progression” was published in Communications Biology. The paper was co-authored by research scientists from institutions such as McGill University, Université de Montréal, Yale University, and Rush Universi...
Study of Neuroepithelial Genetic Markers and Prognosis in High-Grade Gliomas Background and Research Motivation High-grade gliomas are highly malignant brain tumors with generally poor patient prognosis. Previous preclinical model studies have suggested that interactions between neural and tumor cells drive tumor growth, but clinical validation of ...
Alzheimer’s Disease Research and Treatment Frontiers: Beta/Theta Power Ratio in EEG Periodic Components as a Potential Biomarker Background Introduction Alzheimer’s dementia (AD) is a progressively developing disease, accounting for 60% to 80% of all dementia cases [1]. In the early stages of AD, mild cognitive impairment (MCI) typically occurs, du...
Study on Theta Oscillations in Hippocampus-Prefrontal Interaction Supporting Sequential Working Memory Academic Background The dorsolateral prefrontal cortex (DLPFC) and the hippocampus play crucial roles in sequential working memory, but the specific interaction mechanisms are not yet clear. Previous studies have shown that these two brain regions...
Enhancement of Theta and Alpha Oscillations Prior to Crossmodal Memory Encoding Background Episodic memory is a crucial component of human memory, with one of its core mechanisms being the formation of associations through stimuli from different sensory channels. Current theories suggest that during crossmodal associative encoding, the phase and po...