The Antitumor Effect of Dual Inhibition of NAMPT and PAK4 in a 3D Spheroid Model of Platinum-Resistant Ovarian Cancer Platinum-resistant ovarian cancer is a malignant gynecological tumor that is difficult to treat and has a short patient survival period. In recent years, researchers have sought new treatment strategies, targeting cancer stem cells ...
Enhanced EMT Characteristics Associated with Unfavorable Tumor Microenvironment, Angiogenesis, and Poorer Prognosis in Gastric Cancer Academic Background Epithelial-Mesenchymal Transition (EMT) is an extremely important mechanism that promotes the metastasis of cancer cells. However, despite its apparent importance, the clinical significance of EMT...
LOXL1-AS1 Promotes Cholangiocarcinoma Progression by Regulating the JAK2/STAT3 Signaling Pathway Academic Background Cholangiocarcinoma (CCA) is a malignant tumor originating from biliary epithelium, presenting significant medical challenges. Its incidence shows geographical variation, being particularly high in Asia and South America. The occurren...
Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...
Romidepsin Exhibits Anti-Esophageal Squamous Cell Carcinoma Activity through DDIT4-mTORC1 Pathway Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies globally, with high incidence and mortality rates. Given the limited current treatment options, there is an urgent need to develop new effective therapeutic drugs. I...
Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...
AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...
Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...
Precise and Safe Lung Segmentectomy Enabled by Dual-Channel Near-Infrared Fluorescence Tumor and Pleural Demarcation Lung cancer is a leading cause of cancer-related deaths globally. Since the introduction of computed tomography screening, the early detection rate of lung cancer has greatly increased, significantly reducing mortality rates. Studies...
The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...