Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Medical Imaging,
prehospital lactate levels   traumatic brain injury   in-hospital mortality   Glasgow Coma Scale   emergency care  

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency

Medicine, Pediatrics, Obstetrics and Gynecology, Neurology, Medical Imaging,
Pyruvate Dehydrogenase   Complex Deficiency   Fetal MRI   Brain Abnormalities   Genetic Disorder   Second Trimester Diagnosis  

Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...

Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging,
Down Syndrome   Microbleeds   Alzheimer's Disease   Biomarkers   Imaging  

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...

Clinicopathologic and Neuroimaging Correlations of Nonverbal Oral Apraxia in Patients with Neurodegenerative Disease

Medicine, Basic Medical Sciences, Neurology, Medical Imaging,
Nonverbal Oral Apraxia   Neurodegenerative Disease   Clinicopathologic   Neuroimaging   Progressive Supranuclear Palsy   Corticobasal Degeneration  

Nonverbal Oral Apraxia in Patients with Neurodegenerative Diseases: Clinical-Pathological and Neuroimaging Correlations Research Background Nonverbal Oral Apraxia (NVOA) is a condition characterized by the inability to plan, sequence, and execute voluntary oral-facial movements without muscle weakness. NVOA was first identified in stroke patients, ...

Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011–2022

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences,
Primary Progressive Aphasia   Primary Progressive Apraxia of Speech   Epidemiology   Prospective Study   Radiographic Characteristics  

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

Graded Multidimensional Clinical and Radiologic Variation in Patients with Alzheimer Disease and Posterior Cortical Atrophy

Medicine, Geriatrics, Neurology, Clinical Psychology, Medical Imaging,
Alzheimer Disease   Posterior Cortical Atrophy   Cognitive Impairments   Brain Volumes   Neuroimaging  

Research Report on Progressive Multidimensional Clinical and Radiological Variations in Patients with Alzheimer’s Disease and Posterior Cortical Atrophy Background Introduction Alzheimer’s Disease (AD) has multiple phenotypes, including the typical amnestic and non-amnestic (atypical) phenotypes. Posterior Cortical Atrophy (PCA) is a prominent atyp...

Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Parkinson's disease   brain network   α-synuclein   diffusion-weighted imaging   network resilience  

Scientific Paper News Report: Pathological Basis and Topological Properties of Structural Brain Networks in Parkinson’s Disease Patients Background and Research Objectives In Parkinson’s disease (PD), α-synuclein spreads between connected brain regions, leading to neuronal loss and brain network disruption. Using diffusion-weighted imaging (DWI), t...

Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age from Blind Ultrasound Sweeps

Information Science, Artificial Intelligence, Medicine, Obstetrics and Gynecology, Medical Imaging,
integrated AI tool   gestational age estimation   diagnostic accuracy   blind ultrasound sweeps   low-resource settings   pregnancy care   obstetrical sonography  

Diagnostic Accuracy of AI Tools for Estimating Gestational Age Based on Blind Ultrasound Scanning Background Accurate estimation of gestational age (GA) is the foundation of good prenatal care, typically achieved through ultrasound examinations. However, many low-resource areas lack sufficient ultrasound equipment, making accurate GA estimation cha...

Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as Well as Complex Blood and Vascular Pathologies in Alzheimer’s Disease

Medicine, Neurology, Hematology, Medical Imaging, Life Sciences, Cell Biology, Biochemistry,
Senile plaque   Blue autofluorescence   Aβ   Amyloid aggregation   Hemoglobin   Cathepsin D   Microaneurysm   Alzheimer's disease  

Blue Autofluorescence Generated by Aβ Aggregation Illuminates Senile Plaques and Complex Blood and Vascular Pathologies in Alzheimer’s Disease Research Background Alzheimer’s disease (AD) is a widespread neurodegenerative disorder globally, with senile plaques being the main pathological hallmark of AD, primarily composed of β-amyloid protein (Aβ)....

Smart (Splitting‑Merging Assisted Reliable) Independent Component Analysis for Extracting Accurate Brain Functional Networks

Information Science, Computer Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging,
independent component analysis   functional magnetic resonance imaging   brain functional networks   clustering   multi-model-order  

Smart Independent Component Analysis (SMART ICA): An Innovative Method for Extracting Accurate Brain Functional Networks Background Introduction In brain science research, Functional Networks (FNs) show great potential for understanding human brain function by exploring the integration and interaction relationships between different brain regions. ...