Compact and Aberration Effects-Shielded Objective Intraocular Scatter Measurement System

Research Advances on a Novel Compact Double-Pass Intraocular Scatter Measurement System Academic Background According to the World Health Organization (WHO), cataracts are the leading cause of blindness globally, accounting for approximately 50% of all blindness cases. More than 20 million people worldwide suffer from vision loss or severe impairme...

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels

Demonstration of Femtosecond Laser Induced Refractive Index Change in Silk-Fibroin Hydrogels: A New Hope for Future Ophthalmic Biocompatible Implants In today’s era of advanced biotechnology and rapid developments in the biomedical field, refractive correction techniques have become a global research hotspot in ophthalmology. However, current corre...

Comparative Numerical Analysis of Astigmatism Tolerance in Bifocal, Extended Depth-of-Focus, and Trifocal Intraocular Lenses

Numerical Analysis Enhances Postoperative Visual Assessment and Optimization for Multifocal Intraocular Lenses (IOLs) Introduction and Research Background One of the main goals of cataract surgery is to achieve spectacle-free vision for patients. However, this goal is limited by two major challenges: loss of accommodative function and postoperative...

Neural Network Powered Microscopic System for Cataract Surgery

Neural Network Powered Microscopic System for Cataract Surgery

Neural Network-Powered Microsurgical System: Advancing Precision in Cataract Surgery Academic Context and Research Problem Cataracts are the leading cause of blindness worldwide. Phacoemulsification combined with intraocular lens (IOL) implantation has emerged as the primary treatment method. This approach not only significantly improves patients’ ...

Development of a Novel Label-Free Functional, Molecular, and Structural Imaging System Combining Optical Coherence Tomography and Raman Spectroscopy for In Vivo Measurement of Rat Retina

Development of a Novel Label-Free Functional, Molecular, and Structural Imaging System Combining Optical Coherence Tomography and Raman Spectroscopy for In Vivo Measurement of Rat Retina

A Revolution in Optical Imaging: Development of a Multimodal Retinal Imaging System Combining OCT and Raman Spectroscopy Research Background and Significance Accessing molecular information of retinal tissue is pivotal for the early diagnosis of ophthalmic and neurodegenerative diseases. However, the current gold standard in retinal imaging—Optical...

Feasibility Using a Compact Fiber Optic Sagnac Interferometer for Non-Contact Soft Tissue Surface Mechanical Wave Speed Detection

Feasibility Using a Compact Fiber Optic Sagnac Interferometer for Non-Contact Soft Tissue Surface Mechanical Wave Speed Detection

Exploring the Potential of Fiber Optic Sagnac Interferometer in Non-Contact Elasticity Characterization of Soft Tissues Introduction The mechanical properties of soft tissues are critical to modern medicine and biomedical research. Understanding these properties provides significant insights into structural integrity and potential pathological cond...

Development of Next Generation Low-Cost OCT Towards Improved Point-of-Care Retinal Imaging

Development of Next-Generation Low-Cost Optical Coherence Tomography (OCT) Systems: Advancing Retinal Imaging for Clinical Applications Academic Background Optical Coherence Tomography (OCT) is a non-invasive, high-resolution imaging technology widely used in ophthalmology, particularly for diagnosing retinal diseases. However, existing commercial ...

Evaluation of Electrical Impedance Spectroscopy of Bovine Eyes for Early Detection of Uveal Melanoma

Evaluation of Electrical Impedance Spectroscopy of Bovine Eyes for Early Detection of Uveal Melanoma

Early Detection of Uveal Melanoma Using Electrical Impedance Spectroscopy Academic Background Uveal Melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high aggressiveness, which can lead to vision loss and even life-threatening outcomes. Early detection and timely treatment are crucial for preserving vision ...

Oscillatory Transcranial Electrical Stimulation and the Amplitude-Modulated Frequency Dictate the Quantitative Features of Phosphenes

Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...

GCN2-SLC7A11 Axis Coordinates Autophagy, Cell Cycle, and Apoptosis and Regulates Cell Growth in Retinoblastoma upon Arginine Deprivation

GCN2-SLC7A11 Axis Regulates Cell Growth and Survival in Retinoblastoma Under Arginine Deprivation Background Retinoblastoma (RB) is a common intraocular malignant tumor in children, accounting for 4% of all childhood cancers. Although current treatments such as chemotherapy are effective in some patients, they have drawbacks such as multidrug resis...