Racial Disparities in Genetic Detection Rates for Inherited Retinal Diseases Academic Background Inherited retinal diseases (IRDs) are a group of degenerative retinal disorders caused by genetic mutations, which can lead to vision loss or even blindness. With advances in gene discovery and next-generation DNA sequencing, an increasing number of pat...

Academic Background and Problem Statement Fibroblast growth factor receptor inhibitors (FGFRi) are a class of targeted drugs used to treat intrahepatic cholangiocarcinoma (iCCA). Although FGFRi has shown significant efficacy in treating iCCA, the potential complications associated with their long-term use have not been fully studied. In particular,...

Primary Open-Angle Glaucoma Polygenic Risk Score and Risk of Disease Onset: A Post Hoc Analysis Academic Background Primary open-angle glaucoma (POAG) is the most common form of glaucoma, often associated with elevated intraocular pressure (IOP). It is an irreversible optic neuropathy that, if untreated, can lead to vision loss. While IOP-lowering ...

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...

Academic Background Age-related macular degeneration (AMD) is a major cause of central vision loss among the elderly, particularly in its neovascular (NV) form, where choroidal neovascularization (CNV) leads to rapid and severe vision loss. Current AMD treatments primarily rely on intravitreal injections of anti-vascular endothelial growth factor (...

Academic Background and Problem Statement Retinopathy of Prematurity (ROP) is a common retinal neurovascular disorder in premature infants, primarily occurring in those whose retinal vascular development is incomplete. Due to exposure to a relatively hyperoxic environment after birth, especially with supplemental oxygen therapy, hyperoxia suppresse...

Report on the Study of Inflammasome Activation Aggravating Choroidal Neovascularization Academic Background Age-related macular degeneration (AMD) is a common retinal disease, particularly among the elderly. AMD is divided into dry and wet types, with wet AMD characterized by choroidal neovascularization (CNV), where abnormal blood vessels grow fro...

Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels Academic Background Retinal pigment epithelial cells (RPE cells) play a crucial role in various functions of the retina, including responding to stress and damage in the neuroretina. In many neurodegenerative diseases, such as age-related macular degenerat...

Report on Stochastic Structured Illumination Microscopy (S2IM): Scan-less Super-Resolution Imaging Academic Background In the field of super-resolution microscopy, traditional Structured Illumination Microscopy (SIM) techniques rely on precise mechanical control and micron-scale optical alignment to achieve high-resolution imaging. However, these t...

Gut Microbiota-Derived Indole-3-Acetic Acid (3-IAA) Suppresses High Myopia Progression by Promoting Type I Collagen Synthesis Background High myopia (HM) is a serious vision-threatening ocular condition associated with complications such as glaucoma, cataracts, and macular degeneration. Currently, effective interventions for high myopia are lacking...