Development and Preclinical Validation of 2-Deoxy 2-[18F]Fluorocellobiose as an Aspergillus-Specific PET Tracer

Medicine, Infectious Diseases, Medical Laboratory Science, Medical Imaging, Life Sciences, Biochemistry, Immunology, Microbiology,
Aspergillus   PET tracer   2-Deoxy 2-[18F]Fluorocellobiose   Invasive fungal infections   Sugar metabolism   Radiolabeled tracer  

Academic Report The incidence of global Invasive Fungal Infections (IFIs) has increased over the past few decades, primarily affecting immunocompromised patients, and these infections are often associated with high mortality and morbidity rates. Aspergillus fumigatus is one of the most common and deadly IFI pathogens. The main obstacles to effectiv...

Mechanical Ventilation Guided by Driving Pressure Optimizes Local Pulmonary Biomechanics in an Ovine Model

Engineering, Mechanical Engineering, Medicine, Respiratory System, Anesthesiology, Medical Imaging, Life Sciences, Bioengineering,
Mechanical ventilation   Driving pressure   Pulmonary biomechanics   Acute respiratory distress syndrome   Whole-lung image segmentation  

Optimization of Respiratory Pressure Under Mechanical Ventilation Guidance - A Study on Improving Local Lung Biomechanics Mechanical ventilation is commonly used in clinical practice to treat acute respiratory distress syndrome (ARDS) and prevent pulmonary complications after general anesthesia. However, mechanical ventilation can cause harmful str...

Neural Landscape is Associated with Functional Outcomes in Irradiated Patients with Oropharyngeal Squamous Cell Carcinoma

Medicine, Oral Sciences, Neurology, Neurosurgery, Medical Imaging, Oncology, Life Sciences, Immunology,
Neural landscape   Radiation therapy   Oropharyngeal squamous cell carcinoma   Dysphagia   Neuronal changes   Quality improvement   Functional outcomes  

Research on the Association between Neural Networks and Functional Outcomes in Radiotherapy Patients with Pharyngeal Cancer 1. Paper Background Introduction The incidence of human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma (OPSCC) has significantly increased over the past 40 years, especially among younger populations with ...

Translating Potential Improvement in the Precision and Accuracy of Lung Nodule Measurements on Computed Tomography Scans by Software Derived from Artificial Intelligence into Impact on Clinical Practice—A Simulation Study

Information Science, Artificial Intelligence, Medicine, Respiratory System, Medical Imaging,
Artificial Intelligence   Simulation   Measurement Accuracy   Lung Nodule   Chest CT   Precision   Nodule Growth  

Potential Improvements in Lung Nodule Measurement Precision in Computed Tomography Using Artificial Intelligence Software and Its Impact on Clinical Practice - A Simulation Study Background Accurate measurement of lung nodules is crucial for the detection and management of lung cancer. Nodule size is the primary basis for risk classification in exi...

Auto-Segmentation of Neck Nodal Metastases Using Self-Distilled Masked Image Transformer on Longitudinal MR Images

Auto-Segmentation of Neck Nodal Metastases Using Self-Distilled Masked Image Transformer on Longitudinal MR Images

Information Science, Artificial Intelligence, Medicine, Medical Imaging, Oncology,
deep learning   convolutional neural network   neck nodal metastases   auto-segmentation   self-supervised learning   vision transformers  

Potential of Self-Distilling Masked Image Transformer in Longitudinal MRI - Automatic Segmentation of Cervical Lymph Node Metastases Report Introduction In tumor radiotherapy, automatic segmentation technology promises to improve speed and reduce inter-reader variability caused by manual segmentation. In radiotherapy clinical practice, accurate and...

Imaging Brain Glucose Metabolism In Vivo Reveals Propionate as a Major Anaplerotic Substrate in Pyruvate Dehydrogenase Deficiency

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Biochemistry,
Brain Glucose Metabolism   Pyruvate Dehydrogenase Deficiency   Propionate   Imaging Phenotype   Ketogenic Diet  

Imaging Study of Brain Glucose Metabolism in Patients with Pyruvate Dehydrogenase Deficiency Background In modern mitochondrial medicine, evaluating the spectrum of brain diseases has been a limiting challenge. This limitation hinders our ability to understand the mechanisms behind the imaging phenotypes of the brains of mitochondrial disease patie...

White Matter Microstructural Changes Using Ultra-Strong Diffusion Gradient MRI in Adult-Onset Idiopathic Focal Cervical Dystonia

Medicine, Neurology, Medical Imaging,
white matter   microstructural   MRI   cervical dystonia   adult-onset   idiopathic focal  

Study Report on White Matter Microstructure Changes in Adult-Onset Idiopathic Focal Cervical Dystonia Patients Scientists are dedicated to studying Adult-Onset Idiopathic Focal Cervical Dystonia (AOIFCD), the most common type of idiopathic dystonia in adults. This condition primarily manifests as abnormal neck muscle postures, often accompanied by ...

Prehospital Lactate Levels Obtained in the Ambulance and Prediction of 2-Day In-Hospital Mortality in Patients with Traumatic Brain Injury

Medicine, Emergency Medicine, Medical Laboratory Science, Neurology, Medical Imaging,
prehospital lactate levels   traumatic brain injury   in-hospital mortality   Glasgow Coma Scale   emergency care  

Research Report Background Overview Traumatic Brain Injury (TBI) is one of the leading causes of permanent disability and death worldwide. These disorders are dynamic and evolving, involving progressive brain injury and pathophysiological changes accompanied by multi-system damage. The severity of TBI is typically assessed using the Glasgow Coma Sc...

Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency

Medicine, Pediatrics, Obstetrics and Gynecology, Neurology, Medical Imaging,
Pyruvate Dehydrogenase   Complex Deficiency   Fetal MRI   Brain Abnormalities   Genetic Disorder   Second Trimester Diagnosis  

Abnormalities in Fetal Brain MRI in Pyruvate Dehydrogenase Complex Deficiency Background and Research Objective Pyruvate Dehydrogenase Complex Deficiency (PDCD) is a mitochondrial metabolic disorder caused by pathogenic variants in multiple genes, including PDHA1. Classic neonatal brain imaging features have been described, mainly focusing on devel...

Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Medicine, Psychiatry, Geriatrics, Neurology, Medical Imaging,
Down Syndrome   Microbleeds   Alzheimer's Disease   Biomarkers   Imaging  

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...