Technological Updates in Ultrahigh-Field Animal MRI Systems Academic Background Animal magnetic resonance imaging (MRI) systems play a crucial role in preclinical research, typically offering superior imaging performance compared to conventional human MRI systems. However, achieving high performance in these systems is challenging due to the multif...
Academic Background Voltage imaging is a powerful technique for studying neuronal activity, but its effectiveness is often constrained by low signal-to-noise ratios (SNR). Traditional denoising methods, such as matrix factorization, impose rigid assumptions about noise and signal structures, while existing deep learning approaches fail to fully cap...
Academic Background Duchenne Muscular Dystrophy (DMD) is a genetic muscular disorder and the most common type of muscular dystrophy in Japan. DMD is caused by a mutation in the dystrophin gene on the X chromosome, leading to the absence or defect of the dystrophin protein in muscle fibers. This results in a cascade of events, including increased mu...
Report on Stochastic Structured Illumination Microscopy (S2IM): Scan-less Super-Resolution Imaging Academic Background In the field of super-resolution microscopy, traditional Structured Illumination Microscopy (SIM) techniques rely on precise mechanical control and micron-scale optical alignment to achieve high-resolution imaging. However, these t...
Academic Background and Problem Statement Mitochondria, as crucial organelles in eukaryotic cells, are involved in cellular energy metabolism, signal transduction, and the regulation of cell survival and death. Mitochondrial dysfunction is associated with various human diseases, including neurodegenerative disorders, cardiovascular diseases, diabet...
Multimodal Imaging Study of the Tumor Microenvironment in Colorectal Cancer: Revealing Spatial Heterogeneity Academic Background Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with its complexity and heterogeneity posing significant challenges for treatment and prognosis prediction. The tumor microe...
Rapid 3D Imaging at Cellular Resolution for Digital Cytopathology with a Multi-Camera Array Scanner (MCAS) Academic Background Optical microscopy has long been the standard method for diagnosis in cytopathology. However, traditional whole-slide scanners, while capable of automatically imaging and digitizing large sample areas, are slow and expensiv...
Academic Background Three-dimensional (3D) high-resolution large-volume imaging has remained a significant challenge in the field of biomedical research. Traditional two-dimensional (2D) slice imaging, while capable of providing planar morphological information of tissues and cells, fails to comprehensively display internal 3D structural informatio...
Impact of Dietary Zinc on Stimulated Zinc Secretion MRI in the Healthy and Malignant Mouse Prostate Academic Background Zinc (Zn²⁺) is an essential trace element in biological systems, participating in various physiological processes, including enzyme catalysis, structural regulation of transcription factors, immune system modulation, and cell prol...
Uranium-Free KMnO₄/Pb Staining Enables Imaging of Tissue Architectures in Low Vacuum Scanning Electron Microscopy Academic Background Electron Microscopy (EM) is one of the most powerful tools for studying the ultrastructure of cells and tissues. However, traditional metal staining methods for biological samples often require the use of harmful ura...