Clinical Validation of a Cell-Free DNA Fragmentome Assay for Augmentation of Lung Cancer Early Detection

Clinical Validation Study on the Application of Cell-Free DNA Fragment Analysis in Enhancing Early Detection of Lung Cancer Background Lung cancer is one of the leading types of cancer threatening the health of both men and women globally. Over 125,000 people die from lung cancer in the United States each year, and globally, the number is close to ...

Multiplex Cerebrospinal Fluid Proteomics Identifies Biomarkers for Diagnosis and Prediction of Alzheimer's Disease

Cerebrospinal Fluid Proteomics Study for Diagnosis and Prediction of Alzheimer’s Disease Background and Research Objectives Alzheimer’s disease (AD) is a neurodegenerative disease that leads to memory loss and cognitive decline, and currently, there is no effective cure globally. Traditionally, the pathological features of AD include β-amyloid (Aβ)...

Artifactually Inflates Brain-Wide Functional Connectivity Throughout Functional MRI Scans

Functional Connectivity Across the Brain and Temporally Enhanced Non-neuronal Low-Frequency Oscillation (SLFO) Blood Flow Signal Based on Functional Magnetic Resonance Imaging Scans In the field of neuroscience, a core question is how the brain’s connectivity reconfigures over time to support adaptive functional changes. These dynamically changing ...

Long-term Intravital Subcellular Imaging with Confocal Scanning Light-Field Microscopy

Long-term Intravital Subcellular Imaging with Confocal Scanning Light-Field Microscopy

Breakthrough in Long-term Live Subcellular Imaging: Study of Confocal Scanning Light-Field Microscopy Research Background Long-term live cell dynamic observation is indispensable in studying physiological pathological processes such as immune response and brain function, requiring high spatiotemporal resolution and low phototoxicity. Existing confo...

A Bicoherence Approach to Analyze Multi-Dimensional Cross-Frequency Coupling in EEG/MEG Data

Academic News Report on Multidimensional Cross-Frequency Coupling Analysis in EEG/MEG Data In recent years, with the advancement of neuroscience and medical imaging technology, researchers’ exploration of brain functional connectivity has become increasingly in-depth. This report will introduce a scientific research paper on multi-dimensional cross...

Prediction error processing and sharpening of expected information

Prediction error processing and sharpening of expected information

Scientific Report Background Introduction Perception and neuronal processing of sensory information are largely influenced by prior expectations. Perception is not merely passive reception, but an active inferential process by combining existing sensory information with prior information based on past experience and current context. The combination...

Electrophysiological Signatures of Veridical Head Direction in Humans

Electrophysiological Signatures of Veridical Head Direction in Humans

Electrophysiological Signatures of Veridical Head Direction in Humans Navigation is one of the core components of human complex cognition, where head direction information is crucial for positioning oneself in space. However, due to the requirement of having the head fixed in a specific position during most neuroimaging experiments, understanding h...

Brain mechanisms underlying the emotion processing bias in treatment-resistant depression

Brain Mechanism Study on Emotion Processing Bias in Patients with Highly Treatment-Resistant Depression Background Introduction Depression is one of the mental diseases prevalent in modern society that severely affect individuals’ physical and mental health. According to Beck’s cognitive model, the development and maintenance of depression are larg...

Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception

Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception

Research Background and Objectives Empathy is the ability to understand and share the feelings of others and is a crucial foundation for human social interaction and prosocial behavior. Current neuroimaging studies have identified specific brain regions that play key roles in empathetic pain, including the anterior insula (AI), anterior cingulate c...

Differential Cortical Layer Engagement During Seizure Initiation and Spread in Humans

Differential Cortical Layer Engagement During Seizure Initiation and Spread in Humans

Study on the Differences in Cortical Layers During Epileptic Seizure Onset and Spread Epilepsy is a neurological disorder that severely impacts patients’ quality of life, affecting approximately 1% of the global population. Among all epilepsy patients, nearly one-third are resistant to pharmaceutical treatments, known as drug-resistant epilepsy. Fo...