Risk Factors for Domain-Specific Neurocognitive Outcome in Pediatric Survivors of a Brain Tumor in the Posterior Fossa – Results of the HIT 2000 Trial

Medicine, Pediatrics, Neurology, Neurosurgery, Clinical Psychology, Oncology,
Neurocognitive outcome   Pediatric brain tumor   Posterior fossa   HIT 2000 trial   Risk factors analysis  

Analysis of Risk Factors Related to Specific Domain Neurocognitive Outcomes in Pediatric Survivors of Posterior Fossa Brain Tumors – HIT 2000 Trial Results Research Background Brain tumors are the most common solid tumors in childhood, particularly central nervous system (CNS) tumors. Studies have shown that patients who receive craniospinal irradi...

Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Dissecting Gene Expression Networks in the Developing Hippocampus through the Lens of NEIL3 Depletion

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Cell Biology,
hippocampal development   postnatal maturation   hippocampal transcriptome   gene expression network   differential gene expression   NEIL3 DNA glycosylase  

Analyzing the Gene Expression Network in Developing Hippocampus from the Perspective of NEIL3 Deficiency Background The hippocampus, a crucial region of the brain, is well-regarded for its key roles in memory consolidation, information processing, and emotional regulation. In the field of neuroscience research, the gene regulatory mechanisms of the...

Low-Intensity Ultrasound Ameliorates Brain Organoid Integration and Rescues Microcephaly Deficits

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Bioengineering, Biophysics,
brain organoid   low-intensity ultrasound   neural progenitor cells   microcephaly   circuit integration  

Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...

Transient Brain Structure Changes After High Phenylalanine Exposure in Adults with Phenylketonuria

Medicine, Pediatrics, Neurology, Medical Imaging,
Phenylketonuria   Surface-based morphometry   Cognition   Intervention   Randomized controlled trial   Recovery  

The Impact of High Phenylalanine Exposure on Brain Structure in Adult Phenylketonuria Patients Background Phenylketonuria (PKU) is a rare hereditary metabolic disorder characterized by a deficiency of phenylalanine hydroxylase, leading to elevated levels of phenylalanine (Phe) in the blood and brain. If Phe levels are not strictly controlled during...

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Medicine, Pediatrics, Neurosurgery, Oncology,
childhood glioma   late mortality   morbidity   radiation therapy   chemotherapy  

This is a long-term outcome study on survivors of pediatric glioma. The main purpose of the study was to evaluate the impact of changes in treatment approaches for pediatric glioma over the past few decades on long-term mortality, chronic health conditions, and subsequent tumor risk among survivors. Background: In the past, treatment for pediatric ...

Targeting pathological cells with senolytic drugs reduces seizures in neurodevelopmental mTOR-related epilepsy

Medicine, Pediatrics, Neurology,
mTOR pathway   epileptic seizures   cellular senescence  

This is a research report on focal cortical dysplasia (FCD) type II. The authors aim to investigate the cellular senescence phenomenon present in FCD II and whether targeting these senescent cells can alleviate seizures. Background: FCD II is a common cortical malformation causing childhood epilepsy and developmental delay. It is caused by somatic ...

Demonstrated Efficacy and Mechanisms of Sensitivity of ONC201 in H3K27M-Mutant Diffuse Midline Glioma

Demonstrated Efficacy and Mechanisms of Sensitivity of ONC201 in H3K27M-Mutant Diffuse Midline Glioma

Medicine, Pediatrics, Neurology, Oncology,
ONC201   H3K27M-DMG   tumor treatment   mechanism study   clinical trial  

Review of Two New Studies on ONC201 Treatment for H3K27M-Mutant Diffuse Midline Glioma (H3K27M-DMG) This review reports on two new studies investigating the small molecule compound ONC201 for the treatment of H3K27M-mutant diffuse midline glioma (H3K27M-DMG). Background: H3K27M-DMG is an aggressive primary brain tumor that predominantly affects chi...

Treatment response as surrogate to predict risk for disease progression in pediatric medulloblastoma with persistent MRI lesions after first-line treatment

Medicine, Pediatrics, Neurosurgery, Medical Imaging, Oncology,
medulloblastoma   persistent lesions   treatment response   disease progression   prognosis prediction  

Response to First-Line Treatment of Persistent MRI Lesions in Pediatric Medulloblastoma as a Surrogate Marker for Predicting Risk of Disease Progression Medulloblastoma is one of the most common malignant central nervous system tumors in children. Although the multimodal treatment concept has significantly improved the prognosis for patients, the o...