Dual-Inhibition of NAMPT and PAK4 Induces Anti-Tumor Effects in 3D-Spheroids Model of Platinum-Resistant Ovarian Cancer

The Antitumor Effect of Dual Inhibition of NAMPT and PAK4 in a 3D Spheroid Model of Platinum-Resistant Ovarian Cancer Platinum-resistant ovarian cancer is a malignant gynecological tumor that is difficult to treat and has a short patient survival period. In recent years, researchers have sought new treatment strategies, targeting cancer stem cells ...

The Microbial Metabolite Agmatine Acts as an FXR Agonist to Promote Polycystic Ovary Syndrome in Female Mice

Microbial Metabolite Ethylamine as FXR Agonist Promotes Polycystic Ovary Syndrome in Female Mice I. Research Background and Objectives Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting 6%-20% of women of reproductive age worldwide. Symptoms of PCOS include hyperandrogenemia, ovarian dysfunction, and polycystic ...

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment

Distillation of Multi-Class Cervical Lesion Cell Detection via Synthesis-Aided Pre-Training and Patch-Level Feature Alignment Background and Research Significance Cervical cancer is a disease that seriously threatens the life and health of women. According to data from the International Agency for Research on Cancer (IARC), there were approximately...

A Cervical Elastography System Based on Transvaginal Ultrasound Imaging

A Method for Quantifying Cervical Elasticity During Pregnancy Based on Transvaginal Ultrasound and Pressure Measurement Background and Motivation Preterm birth (delivery before 37 weeks of gestation) is a major cause of neonatal morbidity and mortality. Due to the high risks associated with preterm birth, many pregnant women with preterm symptoms n...