Collecting Duct NCOR1 Controls Blood Pressure by Regulating Mineralocorticoid Receptor

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...

Kidney Fibrosis in In Vitro and In Vivo Models: Path Toward Physiologically Relevant Humanized Models

Mechanisms and Research Models of Kidney Fibrosis: Progress Toward Physiologically Relevant Humanized Models Research Background and Problem Statement Chronic Kidney Disease (CKD) is a major global public health issue, estimated to affect more than 10% of the population and is one of the leading causes of mortality. Kidney fibrosis, as a key pathol...

Macrophage Membrane-Camouflaged Nanozymes for Combating Oxidative Stress-Microvascular Perfusion Negative Feedback in Ischemia-Reperfusion Induced Acute Kidney Injury

Innovative Research Report on Intravenous Macrophage Membrane-Camouflaged Nanozymes for Acute Kidney Injury Targeted Therapy Background Introduction Acute kidney injury (AKI) is a severe clinical syndrome characterized by a rapid decline in renal function and is closely associated with high morbidity and mortality. Statistics show that the incidenc...

APOBEC3C-mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression

APOBEC3C-Mediated NF-κB Activation Enhances Clear Cell Renal Cell Carcinoma Progression Academic Background Clear cell renal cell carcinoma (CCRCC) is the most common subtype of kidney cancer, accounting for approximately 75% of all kidney cancer cases. Although immunotherapy has shown some potential in treating CCRCC, the treatment of metastatic C...

SIRCLE Model Reveals Mechanisms of Phenotype Regulation in Renal Cancer

Executive Report on the Study of ccRCC Regulatory Mechanisms Using the SIRCLE Model Background Overview Clear Cell Renal Cell Carcinoma (ccRCC) is the most prevalent form of kidney cancer, accounting for 70% of renal malignancies. The development and progression of ccRCC involve intricate remodeling of the kidney epigenome, transcriptome, proteome,...

Comparative Efficacy of Balanced Crystalloids versus 0.9% Saline on Delayed Graft Function and Perioperative Outcomes in Kidney Transplantation: A Meta-Analysis of Randomised Controlled Trials

Comparative Efficacy of Balanced Crystalloids versus 0.9% Saline on Delayed Graft Function and Perioperative Outcomes in Kidney Transplantation: A Meta-Analysis of Randomised Controlled Trials Academic Background Kidney transplantation is an effective treatment for end-stage renal disease (ESRD), but delayed graft function (DGF) post-transplantatio...

Mortality Risk Prediction Models for People with Kidney Failure: A Systematic Review

Systematic Review of Mortality Risk Prediction Models for Patients with Kidney Failure Academic Background Kidney failure is a severe chronic condition, with a significant decline in both quality of life and survival rates compared to patients with other chronic diseases, including some forms of non-metastatic cancer. Patients with kidney failure o...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...

Study of a Novel NUMB Loss-of-Function Mutation Leading to Hyperuricemia and Gout

NUMB Gene Variant: A Novel Mechanism in Gout Development Background Gout is one of the most common forms of inflammatory arthritis worldwide, primarily triggered by the persistent elevation of serum uric acid levels, known as hyperuricemia. Hyperuricemia leads to the deposition of urate crystals, resulting in inflammation of joints and other tissue...

Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...