Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank

Research Background: Suicide is a global public health challenge, but there is still significant uncertainty regarding the relationship between behavioral and physiological factors and suicide attempts (SA). Previous studies often focus on limited hypothesized factors such as mental illnesses (e.g., depression), personality and psychological traits...

The Necessity of Human Ventromedial Prefrontal Cortex in Prosocial Motivation

The Necessity of the Human Ventromedial Prefrontal Cortex for Prosocial Motivation Research Background and Motivation The ventromedial prefrontal cortex (vmPFC) plays a crucial role in decision-making processes. Functional neuroimaging studies indicate that the vmPFC is key in handling rewards and efforts and is also associated with prosocial behav...

Brain mechanisms underlying the emotion processing bias in treatment-resistant depression

Brain Mechanism Study on Emotion Processing Bias in Patients with Highly Treatment-Resistant Depression Background Introduction Depression is one of the mental diseases prevalent in modern society that severely affect individuals’ physical and mental health. According to Beck’s cognitive model, the development and maintenance of depression are larg...

Cortical Gene Expression Architecture links Healthy Neurodevelopment to the Imaging, Transcriptomics and Genetics of Autism and Schizophrenia

Research Report: The Connection Between Cortical Gene Expression and Neurodevelopmental Disorders Research Background The anatomical and functional organization of the human brain is the result of the coordinated expression of numerous genes. It has been found that the first principal component (c1) of cortical gene expression plays a significant r...

Gamma Oscillations of Visual Cortex Underlying Emotion and Cognition Deficits Associated with Suicide Attempt in Major Depressive Disorder

Research on Gamma Oscillations Related to Suicidal Behavior in Patients with Depression Introduction Suicide is one of the most severe human behaviors globally, particularly prevalent among patients with Major Depressive Disorder (MDD). Studies have shown that nearly half of those who die by suicide had been diagnosed with MDD. Despite its signific...

k-emophone: a mobile and wearable dataset with in-situ emotion, stress, and attention labels

Scientific Data Report | K-emophone: A Mobile and Wearable Dataset with On-site Emotion, Stress, and Attention Labels Background With the proliferation of low-cost mobile and wearable sensors, numerous studies have leveraged these devices to track and analyze human mental health, productivity, and behavioral patterns. However, despite the developme...

Modulating the Difficulty of a Visual Oddball-like Task and P3m Amplitude

Modulation of P3m Amplitude by Task Difficulty in a Visual Oddball Task Background In cognitive neuroscience research, Event-Related Potentials (ERP) and Event-Related Fields (ERF) are important means to explore the cognitive processing mechanisms of the brain. Among these, the P3 component (referred to as P3m in magnetoencephalography) has garnere...

Macroscale Intrinsic Dynamics are Associated with Microcircuit Function in Focal and Generalized Epilepsies

Macroscale Intrinsic Dynamics are Associated with Microcircuit Function in Focal and Generalized Epilepsies

Study on the Relationship between Macroscopic Intrinsic Dynamics and Microcircuit Functions in Epilepsy Research Background Epilepsy is a group of neurological disorders characterized by abnormal spontaneous brain activity, involving multi-scale changes in brain functional organization. However, it remains unclear to what extent epilepsy-related sp...

Graph-based Conditional Generative Adversarial Networks for Major Depressive Disorder Diagnosis with Synthetic Functional Brain Network Generation

Graph-based Conditional Generative Adversarial Networks for Major Depressive Disorder Diagnosis with Synthetic Functional Brain Network Generation

Graph-Based Conditional Generative Adversarial Network for Generating Synthetic Functional Brain Networks to Diagnose Major Depressive Disorder Research Background: Major Depressive Disorder (MDD) is a widespread mental disorder that affects millions of people’s lives and poses a significant threat to global health. Studies have shown that function...

Epilepsy Surgery for Dominant-Side Mesial Temporal Lobe Epilepsy without Hippocampal Sclerosis

Evaluation of Efficacy of Epilepsy Surgery for Dominant Mesial Temporal Lobe Epilepsy without Hippocampal Sclerosis Original Research | Journal of Clinical Neuroscience 111 (2023) 16-21 Introduction Approximately 0.5%-1% of the global population suffers from epilepsy (Fiest et al. 2017), with about 30% of these patients being refractory to medicati...