Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...

Chronic Neuropathic Pain Affects Individual Emotional and Behavioral Disorders, Minocycline Shows Antidepressant Effect in Mouse Models Background Chronic Neuropathic Pain (CNP) has a profound impact on patients’ quality of life, but there are significant differences in individual responses to this pain. Some patients exhibit severe pain-related em...

The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...

Academic Report Research Background In recent years, there has been growing interest in individual differences within the fields of psychology and cognitive neuroscience. However, many studies face a replication crisis, particularly evident in research exploring brain-behavior correlations. A key element for replicable individual differences resear...

Humans Need Auditory Experience to Produce Typical Volitional Nonverbal Vocalizations Introduction This research paper explores whether humans require auditory input to produce nonverbal emotional expressions (such as screams and cries). While these nonverbal vocalizations seem to have a strong reflexive basis, many emotional vocalizations are unde...

Research Report on the Long-term Relationship between Time Perspective and Life Satisfaction in Adulthood Research Background Time perspective is an important predictor of human well-being. However, time perspective itself changes with development. A future-dominated time perspective gradually gives way to a present and past-focused perspective as ...

A Study Report on the Impact of Task Complexity on Digital Health Metrics Evaluation of Upper Limb Function Research Background In patients with neurological diseases such as multiple sclerosis (PWMS), the prevalent upper limb dysfunction significantly affects the completion of daily living activities, increasing dependence on caregivers. To enhanc...

Academic Report on “The Scope Review of Upper Limb Tactile Deficit Examination Methods” In recent years, post-stroke patients’ capacity to perceive tactile stimuli has become a focal point of research. This perception is very important for the execution of movements and learning activities in everyday life. However, tactile perceptual deficits seri...

Systematic Review and Meta-Analysis on the Impact of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cortical Activity - Functional Near-Infrared Spectroscopy (fNIRS) Evaluation Background Repetitive transcranial magnetic stimulation (rTMS) is a device that induces currents within the cerebral cortex through the generation of a magnetic fiel...

Over the past few decades, the incidence of type 2 diabetes mellitus (T2DM) has been on the rise, becoming a global public health issue. T2DM not only affects patients’ metabolic levels but also has profound impacts on cognitive function and mental health. Studies have shown that patients with T2DM exhibit brain structural abnormalities, a decline ...