Study on Quantitative Expression and Treatment Response of Latent Disease Factors Underlying Psychopathological Dimensions Revealed by Unsupervised Machine Learning Research Background Heterogeneity and comorbidity are prevalent in psychiatric diagnoses, posing challenges for precise diagnosis and personalized treatment. For instance, Autism Spectr...
Computational Modeling of Prefrontal-Cingulate Coupling: Exploring Its Role in Balancing Emotion and Cognition Academic Background In recent years, emotional processing and cognitive control, which are crucial for maintaining normal social behavior and executive function, have attracted widespread attention. This study explores how the balance betw...
Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...
Neural Mechanism | Neural Basis of Animal Body Silhouette Classification This article, written by Yue Pu and Shihui Han, published in “neurosci. bull.” in 2024, explores the neural processes of rapid classification and cognition of animal body silhouettes in humans. The study aims to reveal how humans identify and categorize individuals of differen...
Fluoxetine Rescues Excessive Myelin Formation and Psychological Behaviors in a Murine PTSD Model Background Post-traumatic stress disorder (PTSD) is a complex mental disorder characterized by spontaneous intrusions of traumatic memories, avoidance of trauma-related stimuli, negative emotions and cognitions, and hyperarousal. Although existing first...
Gating of Social Behavior by Inhibitory Input from Hippocampal CA1 to Retrosplenial Agranular Cortex Background Social behavior is a fundamental requirement for mammalian survival and reproduction, requiring the perception of sensory information, processing of social relevance, and further integration in the prefrontal cortex. Neuropsychiatric diso...
Research Background and Objectives Autism Spectrum Disorders (ASDs) are a group of highly heritable neurodevelopmental disorders, primarily characterized by abnormal social interactions, communication deficits, and restricted repetitive behaviors or interests. Previous studies have reported structural changes in brain regions including the hippocam...
Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...
Chronic Neuropathic Pain Affects Individual Emotional and Behavioral Disorders, Minocycline Shows Antidepressant Effect in Mouse Models Background Chronic Neuropathic Pain (CNP) has a profound impact on patients’ quality of life, but there are significant differences in individual responses to this pain. Some patients exhibit severe pain-related em...
The Role of BMAL1 in LPS-Induced Depressive Behavior and Related “Inflammatory Storm” Introduction According to the 2019 Global Burden of Disease Study, mental disorders are listed as one of the top 10 causes of global burden, with depression being a major contributor. Over 350 million people worldwide suffer from depression, making it the most com...