A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia Background Insomnia is the second most prevalent psychiatric disorder, affecting nearly one-third of the global population. It not only diminishes quality of life but also increases the risk of cardiovascular diseases, metabolic disorders, mood diso...

The Impairment of Deviant Detection in the Auditory Cortex by the Serotonergic Psychedelic DOI Research Background Psychedelics are a class of psychoactive substances capable of significantly altering perception, cognition, and mood. They have recently regained attention due to their potential therapeutic value, such as in treating depression and a...

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...

Traumatic Experiences, Dissociative Symptoms, and Alexithymia in Patients with Alopecia Areata Academic Background Alopecia Areata (AA) is an inflammatory autoimmune disease targeting hair follicles, with its exact etiology remaining unclear. Studies suggest that genetic, environmental, autoimmune, and psychological factors may play significant rol...

Experience-Dependent Dopamine Modulation of Male Aggression in Mice Academic Background Aggression is a common social behavior in the animal kingdom, crucial for territory defense, resource competition, and mate protection. Although the role of dopamine in regulating aggression has been extensively studied, its specific neural mechanisms remain unc...

Genomic Research on Bipolar Disorder Background Introduction Bipolar Disorder (BD) is a severe mental illness that significantly contributes to the global disease burden. Despite its high heritability (60-80%), the majority of its genetic basis remains unclear. Previous studies have primarily focused on European populations, with limited exploratio...

The Impact of Winter Urban Light on Night-Time Sleep Background Light and darkness are the primary environmental factors regulating human circadian rhythms. In natural environments, humans are exposed to light levels ranging from 3,000 lux (cloudy winter sky) to 100,000 lux (clear sky). However, in modern urban environments, especially during winte...

Study on Laser-Induced Olfactory Bulbectomy in Zebrafish as a Novel Model for Affective Syndrome Background Affective disorders, such as depression, are common mental health issues worldwide. Although rodent models have played a significant role in depression research, their cross-species applicability has limitations. Zebrafish (Danio rerio), as a...

Functional Connectivity of the Default Mode Network During Opioid Use and Cessation Background Opioid abuse has become a global public health issue, particularly in the United States, where opioid overdose deaths have tripled since 1999. Opioids not only lead to addiction but are also associated with chronic pain, immune system suppression, and neu...

The Impairment of Deviance Detection in the Auditory Cortex by DOI Academic Background Psychedelics are a class of psychoactive substances that can significantly alter perception, cognition, and mood. In recent years, psychedelics have shown potential applications in treating conditions such as depression, anxiety, and trauma-related disorders. How...