Study Reveals Molecular Mechanisms of Enhanced Cocaine Craving in Rats During Withdrawal Background Introduction The issue of relapse in drug abuse poses a significant challenge in addiction treatment. According to related research, relapse behaviors in drug addiction are often triggered by environmental cues associated with drug use. This phenomen...

The Regulatory Mechanism of Central Complement C3a Receptor on LPS-Induced Depressive-Like Behavior Introduction With the increasing number of depression patients globally, major depressive disorder (MDD) has become one of the leading causes of disability worldwide. The symptoms, treatment effects, and biological correlations of depression exhibit ...

Analysis of Gender Differences in Transcriptomes of Postmortem Brain Tissues from Psychiatric Patients Background Gender differences in psychiatric patients are a well-documented phenomenon. Disorders such as Schizophrenia (SCZ), Bipolar Disorder (BD), and Autism Spectrum Disorder (ASD) all exhibit significant gender differences. However, the speci...

Insights into the Association Between Sleep and Mortality Revealed by Self-supervised Learning of Wrist-worn Accelerometer Data In modern society, sleep is an essential basic activity for life, and its importance is self-evident. Accurately measuring and classifying sleep/wake states and different sleep stages is crucial for diagnosing sleep disord...

Obsessive-compulsive behaviors have long been associated with overactivation of the striatum. The GABA-ergic parvalbumin-positive interneurons (PVIs) in the striatum play a crucial role in regulating striatal activity and inhibiting inappropriate motivated behaviors. To investigate the potential role of striatal PVIs in regulating obsessive-compuls...

This paper reports a study on the cognitive representation of intracranial self-stimulation (ICSS) of midbrain dopamine neurons. The authors aimed to answer why rats work to obtain ICSS, i.e., how the pulsatile activation of dopamine neurons is represented in the brain. Research Background: The pulsatile activation of dopamine neurons is typically ...

Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...