Academic Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive malignancy. The standard treatment typically involves cisplatin-based neoadjuvant chemotherapy (NAC) or immunotherapy, followed by radical cystectomy (RC) and bilateral pelvic lymph node dissection. However, radical cystectomy significantly impacts patients’ quality of...

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Impact of Dietary Zinc on Stimulated Zinc Secretion MRI in the Healthy and Malignant Mouse Prostate Academic Background Zinc (Zn²⁺) is an essential trace element in biological systems, participating in various physiological processes, including enzyme catalysis, structural regulation of transcription factors, immune system modulation, and cell prol...

NUMB Gene Variant: A Novel Mechanism in Gout Development Background Gout is one of the most common forms of inflammatory arthritis worldwide, primarily triggered by the persistent elevation of serum uric acid levels, known as hyperuricemia. Hyperuricemia leads to the deposition of urate crystals, resulting in inflammation of joints and other tissue...

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Research Background Bladder cancer is a highly prevalent malignant tumor worldwide, ranking as the fourth most common malignancy in men. According to the 2016 report by the National Cancer Center of China (NCCR), bladder cancer ranks sixth in incidence among male malignancies. Despite continuous improvements in medical diagnostic methods and surgic...

Short-term Cold Exposure Induces Persistent Epigenomic Memory in Brown Adipose Tissue Background Brown Adipose Tissue (BAT) is the primary non-shivering thermogenic organ in mammals that dissipates chemical energy as heat under cold stimuli. BAT is characterized by a high density of mitochondria containing Uncoupling Protein 1 (UCP1), which generat...

Transcriptomic Analysis of Prostate Cancer Patients: A Study on Nonlocalized Disease Based on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Academic Background Prostate cancer is a common male malignancy, and its diagnosis and treatment are crucial to patient prognosis. Transcriptomic analysis is a technique us...

Overall Survival and Treatment Patterns in Metastatic Castration-Resistant Prostate Cancer Patients Based on PTEN Status Academic Background Prostate cancer is one of the most common malignant tumors among men worldwide and a leading cause of cancer-related deaths. Approximately 10%-20% of prostate cancer patients will develop castration-resistant ...

Using Cell Cycle Risk Score to Predict the Benefit of Radiotherapy Combined with ADT in Newly Diagnosed Prostate Cancer Patients Background Prostate cancer is one of the most common cancers among men globally. In terms of treatment, localized prostate cancer is often treated primarily with radiotherapy (RT). However, the efficacy of RT alone is oft...