Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer from the Phase III ARANOTE Trial Academic Background Metastatic hormone-sensitive prostate cancer (mHSPC) is a common type of prostate cancer. Patients typically respond to androgen-deprivation therapy (ADT) for a period of ti...

MRI-Guided Micro-US Transperineal Focal Laser Ablation for Localized Prostate Cancer: A 1-Year Follow-Up Study Academic Background Prostate cancer (PCA) is one of the most common malignancies among men worldwide. With the widespread adoption of prostate-specific antigen (PSA) screening, the diagnosis of low-risk prostate cancer has significantly in...

Academic Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive malignancy. The standard treatment typically involves cisplatin-based neoadjuvant chemotherapy (NAC) or immunotherapy, followed by radical cystectomy (RC) and bilateral pelvic lymph node dissection. However, radical cystectomy significantly impacts patients’ quality of...

The Role of lncRNA-Mediated ceRNA Network in Penile Squamous Cell Carcinoma Academic Background Penile Squamous Cell Carcinoma (PSCC) is a relatively rare but life-threatening malignancy that poses a significant health risk to men, particularly in developing countries. Despite advancements in medical diagnosis and treatment, the overall survival ra...

Impact of Dietary Zinc on Stimulated Zinc Secretion MRI in the Healthy and Malignant Mouse Prostate Academic Background Zinc (Zn²⁺) is an essential trace element in biological systems, participating in various physiological processes, including enzyme catalysis, structural regulation of transcription factors, immune system modulation, and cell prol...

NUMB Gene Variant: A Novel Mechanism in Gout Development Background Gout is one of the most common forms of inflammatory arthritis worldwide, primarily triggered by the persistent elevation of serum uric acid levels, known as hyperuricemia. Hyperuricemia leads to the deposition of urate crystals, resulting in inflammation of joints and other tissue...

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...

Research Background Bladder cancer is a highly prevalent malignant tumor worldwide, ranking as the fourth most common malignancy in men. According to the 2016 report by the National Cancer Center of China (NCCR), bladder cancer ranks sixth in incidence among male malignancies. Despite continuous improvements in medical diagnostic methods and surgic...