Review of Two New Studies on ONC201 Treatment for H3K27M-Mutant Diffuse Midline Glioma (H3K27M-DMG) This review reports on two new studies investigating the small molecule compound ONC201 for the treatment of H3K27M-mutant diffuse midline glioma (H3K27M-DMG). Background: H3K27M-DMG is an aggressive primary brain tumor that predominantly affects chi...

Background Introduction: Radiotherapy is a major treatment modality for brain tumor patients, but it can cause cognitive decline as a side effect, which is one of the most concerning complications. Currently, there is a lack of tools in clinical practice to assess the risk of cognitive decline in patients. The purpose of this study is to establish ...