Transient Brain Structure Changes After High Phenylalanine Exposure in Adults with Phenylketonuria

The Impact of High Phenylalanine Exposure on Brain Structure in Adult Phenylketonuria Patients Background Phenylketonuria (PKU) is a rare hereditary metabolic disorder characterized by a deficiency of phenylalanine hydroxylase, leading to elevated levels of phenylalanine (Phe) in the blood and brain. If Phe levels are not strictly controlled during...

Genetics Impact Risk of Alzheimer's Disease through Mechanisms Modulating Structural Brain Morphology in Late Life

In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...

Diffusion Model Optimization with Deep Learning

Diffusion Model Optimization with Deep Learning

Dimond: A Study on Optimizing Diffusion Models through Deep Learning Academic Background In brain science and clinical applications, Diffusion Magnetic Resonance Imaging (dMRI) is an essential tool for non-invasively mapping the microstructure and neural connectivity of brain tissue. However, accurately estimating parameters of the diffusion signal...

Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer’s Disease

Report: Revealing White Matter Changes Associated with Tau in Early Alzheimer’s Disease through Fixel-based Analysis Research Background Alzheimer’s Disease (AD) is generally thought to primarily affect the grey matter (GM), but more and more evidence shows that the white matter (WM) also experiences abnormalities. Current research largely relies o...

DeepDTI: High-Fidelity Six-Direction Diffusion Tensor Imaging Using Deep Learning

DeepDTI: High-Fidelity Six-Direction Diffusion Tensor Imaging Using Deep Learning

DeepDTI: High-Fidelity Six-Direction Diffusion Tensor Imaging Using Deep Learning Research Background and Motivation Diffusion Tensor Imaging (DTI) boasts unparalleled advantages in mapping the microstructure and structural connectivity of live human brain tissue. However, traditional DTI techniques require extensive angular sampling, leading to pr...

Neurophysiological Features of STN LFP Underlying Sleep Fragmentation in Parkinson's Disease

Neurophysiological Features of STN LFP Underlying Sleep Fragmentation in Parkinson's Disease

Parkinson’s Disease (PD) is a neurodegenerative disease primarily characterized by dopaminergic neuron damage. Aside from causing motor disorders, over 80% of Parkinson’s disease patients also suffer from sleep disorders. Fragmented sleep is a common type of sleep disturbance among PD patients. It is associated not only with sleep maintenance insom...

Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study

Research Report: Predictive Role of Cerebrospinal Fluid Routine Parameters in the Disease Process of Multiple Sclerosis Background Multiple Sclerosis (MS) is characterized by a highly variable and unpredictable disease course. In the diagnosis of MS, cerebrospinal fluid (CSF) analysis is often a standard procedure. However, there has been ongoing d...

Nigrostriatal blood-brain barrier opening in Parkinson's disease

Nigrostriatal blood-brain barrier opening in Parkinson's disease

The Opening of the Blood-Brain Barrier in the Nigrostriatal System in Parkinson’s Disease Research Background Parkinson’s disease is a neurodegenerative disorder characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopaminergic transmission in the striatum. Currently, there are...

Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse

This is a multicenter retrospective cohort study on the impact of oral corticosteroid dosage and tapering duration on the time to first relapse in patients with initial presentation of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Background: MOGAD is a unique antibody-associated demyelinating disease. In both children an...

Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment

Circuit-Based Neuromodulation Enhances Delayed Recall Ability in Patients with Mild Cognitive Impairment Introduction As the aging population increases, amnestic mild cognitive impairment (AMCl) is receiving more attention. AMCl is seen as an important transitional stage from normal cognitive function to dementia and is a hotspot for studying cogni...