This is a research report on focal cortical dysplasia (FCD) type II. The authors aim to investigate the cellular senescence phenomenon present in FCD II and whether targeting these senescent cells can alleviate seizures. Background: FCD II is a common cortical malformation causing childhood epilepsy and developmental delay. It is caused by somatic ...
Assessing the Risks of Chemical Exposures for Neurodegenerative Diseases Introduction In recent years, many environmental chemicals, from solvents to pesticides, have been implicated in the development and progression of neurodegenerative diseases. However, a systematic approach akin to genome-wide association studies, which have identified dozens ...
Single-cell sequencing technology reveals unique splicing patterns in developing and adult mouse and human brains In the nervous system, the splicing patterns of messenger RNA (mRNA) play a critical role in establishing cellular identity and regulating cellular functions. However, a comprehensive atlas depicting the mRNA splicing patterns across br...
Linking Healthy Neurodevelopment with Imaging, Transcriptomic, and Genetic Associations in Autism Spectrum Disorder and Schizophrenia: A Study of Cortical Gene Expression Patterns Background: How does the complex anatomy and functional organization of the human brain develop from the expression of more than 20,000 genes? And how does this process g...
This study utilized induced pluripotent stem cell (iPSC)-derived neurons to investigate the critical role of lysosome-related vesicles in axonal mRNA transport and mitochondrial homeostasis maintenance. By knocking out BORC subunits (borcs5 or borcs7) to block the entry of lysosome-related vesicles into axons, researchers found that this led to a s...
This paper was published in the May 2024 issue of Nature Neuroscience, with authors from institutions including the University of Minnesota. The study aimed to address individual differences in brain functional networks by establishing an open-source “Mapping Individual Differences in Brain Networks” (MIDB) resource. Research Background: Although b...
This paper reports an original study on the dynamics of oligodendrocytes in the mouse cortex and white matter using three-photon microscopy. Introduction: Oligodendrocytes are the cells that produce myelin in the central nervous system, which is crucial for neural transmission, cognitive function, and injury repair. Previous studies have shown regi...
Title: Treating Low-Grade Optic Pathway Glioma by Inhibiting Neuronal Activity Introduction: Optic pathway glioma (OPG) is a low-grade glioma commonly found in children with neurofibromatosis type 1 (NF1). NF1 is a common neurocutaneous syndrome with an incidence of approximately 1⁄3000. Although OPG is a low-grade tumor, it can lead to serious com...
Pediatric brainstem glioblastoma is the most common malignant brain tumor in children, and surgical resection is the primary treatment method. However, posterior fossa surgery may lead to a complication known as “Pediatric Cerebellar Mutism Syndrome (CMS).” CMS is primarily characterized by temporary mutism, motor disorders, and emotional abnormali...
This academic paper reports a study on exosomes in patients with glioblastoma. The study explored the potential application of exosomes as biomarkers in the diagnosis, prognosis, and treatment response monitoring of glioblastoma. Academic Background: Glioblastoma is an invasive brain tumor, and despite comprehensive treatments such as surgery, chem...