Outcomes of Mechanical Thrombectomy for Patients with Stroke Presenting with Low Alberta Stroke Program Early Computed Tomography Score in Early and Late Time Windows

Outcomes of Mechanical Thrombectomy for Stroke Patients with Low Alberta Stroke Program Early CT Score Background Acute ischemic stroke is a life-threatening disease, and large vessel occlusion is one of the major causes of severe disability. Mechanical thrombectomy (MT) has become the standard treatment for acute ischemic stroke, with multiple cli...

Patterns of Sagittal Imbalance in Degenerative Kyphosis and Its Implication on Postoperative Mechanical Failure

Patterns of Sagittal Imbalance in Degenerative Kyphosis and Its Implication on Postoperative Mechanical Failure

Sagittal Imbalance Patterns in Degenerative Kyphosis of the Lumbar or Thoracolumbar Spine and Their Impact on Postoperative Complications Research Background Degenerative kyphosis (DK) is the most common type of spinal deformity in the elderly. Sagittal imbalance is a typical radiological feature of DK and is associated with a severe decline in qua...

Caudal Agenesis: Classification Based on the Pathoembryogenesis of the Spinal Cord

This is a report on a new classification method for caudal agenesis: Caudal agenesis is a congenital disorder characterized by the absence of lower vertebrae. Previous classifications of caudal agenesis were primarily based on the level of bony deficiency or the position of the terminal spinal cord, but there has been debate as to whether these cla...

The Association Between Task Complexity and Cortical Language Mapping Accuracy

Correlation between Task Complexity and Accuracy of Cortical Language Mapping Introduction This study aimed to investigate whether task complexity affects the accuracy of mapping language functions during direct cortical stimulation mapping (DCS). The researchers hypothesized that due to the reduced computational ability of neurons in the cortex in...

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

This is a long-term outcome study on survivors of pediatric glioma. The main purpose of the study was to evaluate the impact of changes in treatment approaches for pediatric glioma over the past few decades on long-term mortality, chronic health conditions, and subsequent tumor risk among survivors. Background: In the past, treatment for pediatric ...

Meningioma: International Consortium on Meningiomas (ICOM) Consensus Review on Scientific Advances & Treatment Paradigms for Clinicians, Researchers, and Patients

Meningiomas are the most common primary intracranial tumors in adults, and their incidence is rising with an aging population and the widespread use of neuroimaging examinations. While most meningiomas are benign, a small portion exhibit biological invasiveness, leading to severe neurological complications and death. In recent years, significant pr...

EDA2R reflects the acute brain response to cranial irradiation

EDA2R Elevation in Liquid Biopsy Reflects Acute Brain Injury after Cranial Radiation Background Cranial radiation therapy is the standard treatment for advanced brain tumors and metastases, but it leads to devastating neurocognitive impairments, especially in childhood cancer survivors. As the number of childhood brain cancer survivors continues to...

Abnormal Functional Connectivity in Brain Regions of Cerebellar Mutism Syndrome Patients After Chemotherapy

Pediatric brainstem glioblastoma is the most common malignant brain tumor in children, and surgical resection is the primary treatment method. However, posterior fossa surgery may lead to a complication known as “Pediatric Cerebellar Mutism Syndrome (CMS).” CMS is primarily characterized by temporary mutism, motor disorders, and emotional abnormali...

Phase I Trial of Dose Escalation for Preoperative Stereotactic Radiosurgery for Patients with Large Brain Metastases

This is a phase I clinical trial that explored the safety of preoperative single-fraction stereotactic radiosurgery (SRS) with dose escalation for patients with brain metastases. The background of this study is that for brain metastases larger than 2cm in diameter, surgery alone or single-fraction SRS alone is difficult to achieve ideal local contr...

Circulating Extracellular Vesicles as Biomarker for Diagnosis, Prognosis and Monitoring in Glioblastoma Patients

This academic paper reports a study on exosomes in patients with glioblastoma. The study explored the potential application of exosomes as biomarkers in the diagnosis, prognosis, and treatment response monitoring of glioblastoma. Academic Background: Glioblastoma is an invasive brain tumor, and despite comprehensive treatments such as surgery, chem...