Radical surgical resection with molecular margins is associated with improved survival in IDH wildtype GBM

Medicine, Basic Medical Sciences, Neurosurgery, Oncology, Life Sciences, Genetics,
glioblastoma   TERT promoter mutation   surgical margin   radical resection   survival  

In this research paper from the journal Neuro-Oncology, the researchers investigated the relationship between the residual tumor cells at the resection margin after surgical removal and the progression-free survival (PFS) and overall survival (OS) in patients with wildtype isocitrate dehydrogenase (IDH wildtype) glioblastoma (GBM). The authors are ...

Treatment response as surrogate to predict risk for disease progression in pediatric medulloblastoma with persistent MRI lesions after first-line treatment

Medicine, Pediatrics, Neurosurgery, Medical Imaging, Oncology,
medulloblastoma   persistent lesions   treatment response   disease progression   prognosis prediction  

Response to First-Line Treatment of Persistent MRI Lesions in Pediatric Medulloblastoma as a Surrogate Marker for Predicting Risk of Disease Progression Medulloblastoma is one of the most common malignant central nervous system tumors in children. Although the multimodal treatment concept has significantly improved the prognosis for patients, the o...

Predicting the risk of neurocognitive decline after brain irradiation in adult patients with a primary brain tumor

Medicine, Neurology, Neurosurgery, Oncology,
brain tumor   radiotherapy   neurocognitive decline   prediction model  

Background Introduction: Radiotherapy is a major treatment modality for brain tumor patients, but it can cause cognitive decline as a side effect, which is one of the most concerning complications. Currently, there is a lack of tools in clinical practice to assess the risk of cognitive decline in patients. The purpose of this study is to establish ...