Evaluation of Efficacy of Epilepsy Surgery for Dominant Mesial Temporal Lobe Epilepsy without Hippocampal Sclerosis Original Research | Journal of Clinical Neuroscience 111 (2023) 16-21 Introduction Approximately 0.5%-1% of the global population suffers from epilepsy (Fiest et al. 2017), with about 30% of these patients being refractory to medicati...

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...

Malignant Glioma (MG) Report Malignant Glioma (MG) is the most common type of primary malignant brain tumor. Surgical resection of MG remains the cornerstone of treatment, and the extent of resection is highly correlated with patient survival. However, it is difficult to distinguish tumor tissue from normal tissue during surgery, which greatly limi...

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...

Multi-Level Feature Exploration and Fusion Network for Prediction of IDH Status in MRI Background Glioma is the most common malignant primary brain tumor in adults. According to the 2021 World Health Organization (WHO) classification of tumors, genotype plays a significant role in the classification of tumor subtypes, especially the isocitrate dehy...

Spinal Cord Injury (SCI) resulting in upper limb paralysis significantly impacts patients’ independence and quality of life. Among the SCI patient population, regaining control over hand and arm movements is considered the highest priority treatment goal, surpassing even the restoration of walking ability. However, current clinical methods to impro...

Feasibility, Safety, and Performance of Full-Scalp Subdural EEG - A Report on Minimally Invasive Electrode Implantation Background and Purpose Since Berger first recorded human scalp electrical signals and discovered the alpha rhythm in 1929, the recording capabilities of electroencephalography (EEG) have significantly improved in terms of spatial ...

Natural History and MRI Follow-up of Patients with Cerebral Cavernous Malformations Background Cerebral cavernous malformations (CCMs) are vascular malformations of the brain and spinal cord lined by endothelial cells and lacking smooth muscle. Due to the disruption of endothelial cell permeability and tight junctions, patients may present with foc...

Accuracy of Frameless Optical Navigation in Stereotactic Laser Interstitial Thermal Therapy Background Glioblastoma is a rapidly growing and invasive brain tumor, and traditional treatment methods include surgical resection, radiation therapy, and chemotherapy. However, for some patients with deep-seated tumors or poor physical conditions, traditio...

In recent years, refractory epilepsy has received increasing attention from the medical community. Refractory epilepsy is defined as the continuing occurrence of severe seizures despite treatment with two appropriate antiepileptic drugs. For patients who are unresponsive to drug treatment, if the seizure onset zone (SOZ) can be accurately localized...