Targeting the Transferrin Receptor to Transport Antisense Oligonucleotides Across the Mammalian Blood-Brain Barrier

Introduction In recent years, oligonucleotide-based therapeutic technologies, such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), have been widely applied in the treatment of various neurological disorders. The basis for their application is that these technologies can selectively regulate target RNA molecules, which are ...

Neural Landscape is Associated with Functional Outcomes in Irradiated Patients with Oropharyngeal Squamous Cell Carcinoma

Research on the Association between Neural Networks and Functional Outcomes in Radiotherapy Patients with Pharyngeal Cancer 1. Paper Background Introduction The incidence of human papillomavirus (HPV)-mediated oropharyngeal squamous cell carcinoma (OPSCC) has significantly increased over the past 40 years, especially among younger populations with ...

Leptin Receptor Reactivation Restores Brain Function in Early-Life lepr-Deficient Mice

Reactivation of Insulin Receptors Can Restore Brain Function in Early Lepr-Deficient Mice Background Obesity is a chronic disease caused by excessive fat accumulation, affecting both body and brain health. Deficiency of the insulin receptor (Leptin receptor, Lepr) is considered an important factor in the pathogenesis of obesity. Insulin plays a cru...

Glycometabolic Reprogramming-Induced XRCC1 Lactylation Confers Therapeutic Resistance in ALDH1A3-Overexpressing Glioblastoma

Background Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults, characterized by high recurrence and mortality rates. Despite active chemotherapy and radiotherapy post-surgery, GBM remains insensitive to existing treatment regimens, and patients usually have a poor prognosis. Recent studies indicate that the...

Timing of Anticoagulation Resumption and Risk of Ischemic and Hemorrhagic Complications in Patients with Intracranial Hemorrhage and Mechanical Heart Valves

Exploration of Anticoagulation Therapy Resumption Time After ICH in Mechanical Heart Valve Patients Background and Motivation For patients with mechanical heart valves, determining the appropriate time to resume oral anticoagulation therapy after experiencing an intracerebral hemorrhage (ICH) remains a significant clinical challenge. These patients...

Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County, MN, 2011–2022

Study on the Incidence of Primary Progressive Apraxia of Speech and Primary Progressive Aphasia in Olmsted County (2011-2022) Background and Study Objectives Primary Progressive Aphasia (PPA) and Primary Progressive Apraxia of Speech (PPAOS) are rare neurodegenerative diseases that respectively lead to the degeneration of language abilities and spe...

p39 Affects Myelin Formation in Cerebral Ischemic Injury

The Role of p39 in Cerebral Ischemic Injury Background Introduction Stroke is an extremely serious public health problem, with current research mainly focusing on injury mechanisms and new target identification. p39, as an activator of CDK5 (Cyclin-dependent kinase 5), plays a crucial role in various diseases. This article mainly investigates the r...

Optogenetic Inhibition of Glutamatergic Neurons in the Dysgranular Posterior Insular Cortex Modulates Trigeminal Neuropathic Pain in CCI-Ion Rat

Optogenetic Inhibition of Insular Cortex Glutamatergic Neurons Regulates Trigeminal Neuropathic Pain Introduction and Background Trigeminal neuropathic pain (TNP) is a severe facial disorder characterized by rapid and intense stabbing pain attacks that spread along the cutaneous segments of the trigeminal nerve. TNP occurs almost twice as frequentl...

PDGFRA, KIT, and KDR Gene Amplification in Glioblastoma: Heterogeneity and Clinical Significance

Brain Glioblastoma PDGFRA, KIT and KDR Gene Amplification: Heterogeneity and Its Clinical Significance Academic Background Glioblastoma (GBM) is the most common malignant tumor of the central nervous system, with its heterogeneity posing significant challenges in treatment. GBM exhibits cellular genetic and phenotypic diversity not only between dif...

Loss-of-function variants in ERF are associated with a Noonan syndrome-like phenotype with or without craniosynostosis

Correlation between Erf Gene Loss-of-Function Variants and Noonan Syndrome-like Phenotype - With or Without Craniosynostosis Research Background Members of the ETS transcription factor family play a crucial role in RAS-MAPK signal transduction, regulating the expression of “early response” genes and other functionally related genes. Among them, ETS...