Evaluation of Epilepsy Seizure Onset Zone (SOZ) Implantation Quality through Spatial Perturbation Framework in Pre-Surgical Planning Background The success of epilepsy surgery relies heavily on the accuracy of pre-surgical planning, which typically involves identifying the epileptic zone (EZ) using clinical symptomatology, electroencephalography (E...
Study on the Differences in Cortical Layers During Epileptic Seizure Onset and Spread Epilepsy is a neurological disorder that severely impacts patients’ quality of life, affecting approximately 1% of the global population. Among all epilepsy patients, nearly one-third are resistant to pharmaceutical treatments, known as drug-resistant epilepsy. Fo...
Consensus Study Report on Pediatric Epilepsy Surgery Background Introduction The incidence of epilepsy varies significantly across different age groups. According to the International League Against Epilepsy (ILAE), the highest incidence rates of epilepsy are found among those under 5 years old and over 65 years old (>60 per 100,000 people), with c...
Clinical Utility of Non-invasive Imaging in MRI-negative Focal Epilepsy Academic Background Epilepsy surgery is a crucial treatment modality for drug-resistant epilepsy. However, the likelihood of achieving good outcomes postoperatively is significantly diminished when Magnetic Resonance Imaging (MRI) fails to detect lesions. Previous studies indic...
Neurophysiological Study: Neurophysiological Research on Orientation Discrimination in a Working Memory Task Background Recognizing and remembering the spatial orientation of the environment is a crucial component of visuospatial behavior. Accurately storing and recalling this information helps us navigate in space and respond adaptively to rapid c...
Study on Theta Oscillations in Hippocampus-Prefrontal Interaction Supporting Sequential Working Memory Academic Background The dorsolateral prefrontal cortex (DLPFC) and the hippocampus play crucial roles in sequential working memory, but the specific interaction mechanisms are not yet clear. Previous studies have shown that these two brain regions...
Evaluation of Efficacy of Epilepsy Surgery for Dominant Mesial Temporal Lobe Epilepsy without Hippocampal Sclerosis Original Research | Journal of Clinical Neuroscience 111 (2023) 16-21 Introduction Approximately 0.5%-1% of the global population suffers from epilepsy (Fiest et al. 2017), with about 30% of these patients being refractory to medicati...
Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...
Malignant Glioma (MG) Report Malignant Glioma (MG) is the most common type of primary malignant brain tumor. Surgical resection of MG remains the cornerstone of treatment, and the extent of resection is highly correlated with patient survival. However, it is difficult to distinguish tumor tissue from normal tissue during surgery, which greatly limi...
Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...