Neoantigen-Specific mRNA/DC Vaccines for Effective Anticancer Immunotherapy

Effectiveness of Neoantigen-Specific mRNA/DC Vaccines in Anticancer Immunotherapy Academic Background Cancer immunotherapy has emerged as a significant breakthrough in cancer treatment in recent years. Among the various approaches, dendritic cell (DC) vaccines have shown potential in extending the survival of some advanced cancer patients. However,...

High Sound Pressure Piezoelectric Micromachined Ultrasonic Transducers Using Sputtered Potassium Sodium Niobate

Advances in High Sound Pressure Piezoelectric Micromachined Ultrasonic Transducers Academic Background Ultrasonic transducers are widely used in object detection, non-destructive testing (NDT), biomedical imaging, and therapeutic treatments. Compared to traditional bulk ultrasonic transducers, piezoelectric micromachined ultrasonic transducers (PMU...

Dynamic 3D Metasurface Holography via Cascaded Polymer Dispersed Liquid Crystal

Dynamic 3D Metasurface Holography via Cascaded Polymer Dispersed Liquid Crystal Academic Background Metasurfaces, as two-dimensional subwavelength structures, enable local modulation of the phase and amplitude of light fields, offering novel solutions for the design of miniaturized optical devices. However, most existing metasurface holographic dis...

Root-Inspired, Template-Confined Additive Printing for Fabricating High-Robust Conformal Electronics

Root-Inspired, Template-Constrained Additive Printing for Fabricating Highly Robust Conformal Electronics Academic Background With the rapid development of emerging application scenarios such as smart robotics, smart skins, and integrated sensing systems, the application of conformal electronic devices on freeform surfaces has become crucial. Howev...

Study on the Piezoresistivity of Cr-Doped V2O3 Thin Film for MEMS Sensor Applications

Study on the Piezoresistivity of Cr-Doped V₂O₃ Thin Film for MEMS Sensor Applications Academic Background Piezoresistive microelectromechanical systems (MEMS) sensors are devices that utilize the piezoresistive effect of a material to convert stress changes, induced by the physical property being observed, into resistance changes. These sensors, su...

Revolutionary Self-Powered Transducing Mechanism for Long-Lasting and Stable Glucose Monitoring: Achieving Selective and Sensitive Bacterial Endospore Germination in Microengineered Paper-Based Platforms

Revolutionary Self-Powered Glucose Monitoring Mechanism: Microengineered Paper-Based Platform with Microbial Spores Academic Background Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels, which can lead to severe complications such as cardiovascular diseases, retinopathy, kidney failure, and neuropathy. The glob...

Automated Analysis of Ultrastructure through Large-Scale Hyperspectral Electron Microscopy

Automated Analysis of Ultrastructure through Large-Scale Hyperspectral Electron Microscopy

Automated Analysis of Ultrastructure: A Study Based on Large-Scale Hyperspectral Electron Microscopy Academic Background Electron Microscopy (EM) is a key technique for studying biological ultrastructure, revealing the fine details of cells at biomolecular resolution. In recent years, advancements in automation and digitization have enabled EM to c...

Nonlinear Coupling of Closely Spaced Modes in Atomically Thin MoS2 Nanoelectromechanical Resonators

Study of Nonlinear Coupling in Atomically Thin MoS₂ Nanoelectromechanical Resonators Academic Background With the rapid development of nanotechnology, Nanoelectromechanical Systems (NEMS) have shown great potential in fields such as sensors, signal processing, and quantum computing. Particularly, two-dimensional (2D) materials like molybdenum disul...

Coupling the Thermal Acoustic Modes of a Bubble to an Optomechanical Sensor

Coupling the Thermal Acoustic Modes of a Bubble to an Optomechanical Sensor Academic Background The acoustic behavior of bubbles in liquids has long been a significant research topic in physics and engineering. The vibrational modes of bubbles are not only closely related to acoustic phenomena in nature but also have broad applications in fields su...

Precision Autofocus in Optical Microscopy with Liquid Lenses Controlled by Deep Reinforcement Learning

Precision Autofocus in Optical Microscopy with Liquid Lenses Controlled by Deep Reinforcement Learning Academic Background Microscopic imaging plays a crucial role in scientific research, biomedical studies, and engineering applications. However, traditional microscopes and autofocus techniques face hardware limitations and slow software speeds in ...