Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Academic Background With the intensification of global climate change, the impact of greenhouse gas (GHG) emissions on the environment and human health is becoming increasingly significant. The healthcare sector, as a major consumer of global energy and resources, contributes substantially to carbon emissions. Statistics show that the healthcare se...

Comparison of Tumor Burden Quantification between Liquid Biopsy and CT Academic Background In the era of precision medicine, the validation of non-invasive biomarkers faces numerous challenges. Tumor burden, as a potential prognostic marker, has been demonstrated to hold significant value in various studies. Tumor burden refers to the total amount ...

The Relationship Between Climate Change and Emergency Medical Imaging Utilization Academic Background Climate change and related environmental exposures have significantly impacted human health, leading to increased demand for healthcare services. High-temperature exposure and poor air quality are closely associated with increased emergency departm...

Association of Plasma GFAP and p-tau-181 with Synaptic Density in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is a multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) plaques and tau protein aggregates in the brain. Recent research has shown that multiple factors are involved in the dev...

Research Background Neuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune central nervous system disease characterized by severe onset and relapse events, including optic neuritis, longitudinally extensive transverse myelitis (LETM), brainstem and/or hypothalamic syndromes, and encephalitis. Most patients have serum immunoglobulin G (IgG)...

Impact of an Epstein-Barr Virus Serology-Based Screening Program on Nasopharyngeal Carcinoma Mortality: A Cluster-Randomized Controlled Trial Academic Background Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Asia, particularly in southern China. Approximately 85% of NPC cases occur in Asia, with the incidence being...