Control of Movement: Kinematic Hand Synergies Differ Between Reach-and-Grasp and Functional Object Manipulation

Human Hand Movement Control—Differences in Kinematics Between Functional Object Manipulation and Grasping Actions Academic Background The functionality of the human hand plays a crucial role in daily life, particularly through its dexterity, which allows us to use tools to complete various complex tasks. However, millions of people lose hand functi...

The Serotonergic Psychedelic DOI Impairs Deviance Detection in the Auditory Cortex

The Impairment of Deviant Detection in the Auditory Cortex by the Serotonergic Psychedelic DOI Research Background Psychedelics are a class of psychoactive substances capable of significantly altering perception, cognition, and mood. They have recently regained attention due to their potential therapeutic value, such as in treating depression and a...

How Does Orientation-Tuned Normalization Spread Across the Visual Field?

Study on Orientation-Tuned Gain Control Mechanisms in the Visual Cortex Academic Background Visual perception is a complex neural process influenced by contextual environments. Surround suppression is an important phenomenon that describes how the perceived contrast of a stimulus is attenuated when surrounded by other stimuli. The neural mechanisms...

Not Fleeting but Lasting: Limited Influence of Aging on Implicit Adaptive Motor Learning and its Short-Term Retention

The Impact of Aging on Implicit Motor Learning and Short-term Memory: A Study Based on Force Field Adaptation Research Background Motor adaptation is the process by which the brain adjusts motor strategies in response to environmental changes, typically involving two mechanisms: explicit learning and implicit learning. Explicit learning is a rapid,...

Probing Sensorimotor Memory through the Human Speech-Audiomotor System

Research Background Human sensorimotor learning and memory mechanisms have long been a research focus in the field of neuroscience. Most related studies have concentrated on the visuospatial workspace and limb movements, such as arm movements and grasping actions. These studies have helped scientists understand how sensorimotor memories are formed,...

Electroacupuncture Ameliorated Locomotor Symptoms in MPTP-Induced Mice Model of Parkinson’s Disease by Regulating Autophagy via Nrf2 Signaling

Study on Electroacupuncture Improving Parkinson’s Disease Symptoms by Regulating Autophagy Academic Background Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, primarily characterized by the gradual loss of dopamine (DA) neurons in the substantia nigra of the midbrain and the abnormal accumulation of α-synucle...

Differential Effects of Stimulation Waveform and Intensity on the Neural Structures Activated by Lumbar Transcutaneous Spinal Cord Stimulation

The Differential Effects of Transcutaneous Spinal Cord Stimulation (TSS) on Neural Structure Activation Background Introduction Transcutaneous Spinal Cord Stimulation (TSS) is a non-invasive neurostimulation technique that applies electrical currents through electrodes on the skin surface to activate neural structures in the spinal cord, thereby el...

Machine Learning and Confirmatory Factor Analysis Show that Buprenorphine Alters Motor and Anxiety-like Behaviors in Male, Female, and Obese C57BL/6J Mice

In recent years, with the global increase in drug abuse, particularly opioids, scientists have become increasingly focused on the neurobehavioral effects of such substances. Among them, buprenorphine, an opioid, is widely used for medication-assisted treatment of opioid addiction. However, beyond its analgesic and addiction treatment effects, bupre...

Dopamine Receptors D1, D2, and D4 Modulate Electrical Synapses and Excitability in the Thalamic Reticular Nucleus

Modulation of Electrical Synapses and Excitability by Dopamine Receptors in the Thalamic Reticular Nucleus Academic Background The Thalamic Reticular Nucleus (TRN) is a thin shell of γ-aminobutyric acid (GABA)ergic inhibitory neurons in the thalamus. These neurons are coupled via gap junctions and regulate the transmission of sensory information fr...

Increased Robustness and Adaptation to Simultaneous Temperature and Elevated Extracellular Potassium in the Pyloric Rhythm of the Crab, Cancer Borealis

Increased Robustness and Adaptation of the Crab Pyloric Rhythm to Simultaneous Temperature and Elevated Extracellular Potassium Academic Background In nature, animals often face multiple simultaneous environmental perturbations, which may include temperature fluctuations, pH variations, salinity changes, and alterations in extracellular potassium c...