Background Introduction In respiratory diseases, the lung is a sensitive organ exposed to the external environment, making it susceptible to pathogens, allergens, and toxic particles. Due to the high morbidity and mortality associated with respiratory diseases (such as asthma), it is crucial to study the mechanisms protecting the cells on the surfa...
Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...
MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...
Differential Study of GPCR-G Protein Coupling Biosensors Background Introduction G protein-coupled receptors (GPCRs) are important molecules for transmembrane signal transduction, capable of selectively binding to heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits and regulating various intracellular signaling processes. Studying the fun...
Academic News Report: The Temporal and Spatial Bias in β-arrestin Signal Transduction Mediated by G Protein-Coupled Receptor Endocytosis Research Background Among cell surface receptor families, G protein-coupled receptors (GPCRs) constitute the largest family. Upon activation by ligands, they interact with various signaling proteins to trigger int...
Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...
Review on the Study of IL-12 Promoting Human Follicular Regulatory T Cell Differentiation Research Background Follicular helper T cells (Tfh) play a crucial regulatory role in B cell responses to pathogens and vaccines. When not properly controlled, Tfh cells can lead to the production of antibodies against self-antigens or allergens. Follicular re...
Mini G Protein Inhibits Internalization of Same GPCR and Disrupts Downstream Intracellular Signaling Introduction G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, regulating cellular responses to external stimuli such as hormones and neurotransmitters. GPCRs transmit signals by coupling with guanine nucleotide-bi...
Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...
YAP Inhibits the TEAD-NF-κB Complex and Suppresses the Growth of Clear Cell Renal Cell Carcinoma Research Background Conventionally, the Hippo signaling pathway inhibits YAP-TEAD transcriptional complexes by keeping the transcriptional coactivator YAP phosphorylated and retained in the cytoplasm, thereby impeding tumor growth. However, researchers ...