Genomic Characteristics of a Rare Pancreatic Cancer Undifferentiated Sarcomatoid Carcinoma Subtype Academic Background Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest cancers, characterized by early invasion and metastasis. Undifferentiated Sarcomatoid Carcinoma (USC) is a particularly aggressive but rare subtype of PDAC, accounting...
Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...
The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...
Timed Step Recommendations to Assist in Achieving Daily Goals - A New Strategy for Working and Elderly Adult Populations With the popularization of health trackers, high-resolution health data (such as hourly step counts) can be collected and used to evaluate health promotion plans. Take daily step goals for example. Research has found that the acc...
The Relationship Between Mask Effectiveness and Population Coverage Rates Background and Research Motivation During the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, mask-wearing, and test-trace-isolate strategies were widely applied to control the spread of the virus. Despite a large body of empirical resear...
Breakthrough in Automated Echocardiogram Diagnosis via Deep Learning: A Comparative Study of Self-Supervised Learning Methods Research Background With the rapid development of artificial intelligence and machine learning technologies, their role in medical imaging diagnosis is becoming increasingly significant. In particular, Self-Supervised Learni...
How to Reduce the Expectations and Demand for Antibiotics in the Face of the Threat of a “Post-Antibiotic Era” Introduction Antibiotic resistance is becoming a global public health threat. Although the evolution of this resistance is a biological process, human behavior, especially unnecessary antibiotic use in agricultural production and human med...
Research on a Unified Metagenomic Method for Rapid Detection of Microorganisms in Clinical Samples Background Introduction The background of this research is based on the current limitations of clinical metagenomics. Clinical metagenomics involves genome sequencing of all microorganisms in clinical samples, ideally performed after depleting human D...
Mapping Multimorbidity Progression Among 190 Diseases Background Globally, with the aging population and the significant increase in the negative impacts of chronic diseases, multimorbidity, the coexistence of multiple long-term conditions, has become an increasingly severe health challenge. Understanding the accumulation process of multimorbidity ...
In the global context, the prevalence of obesity is on the rise, bringing significant impacts to public health. Obesity is independently associated with the incidence and mortality of cardiovascular diseases, with an estimated economic burden exceeding $200 billion annually for healthcare systems. In recent years, glucagon-like peptide-1 (GLP-1) re...