Somatic and Germline PRNP Variants in Sporadic Human Prion Disease: A Neuropathological Study Introduction Prion diseases are a class of infectious, progressive, and fatal neurodegenerative diseases characterized by the pathological folding and aggregation of prion protein (PrP). Prion protein is encoded by the PRNP gene, with normal cellular prion...
Cerebral amyloid angiopathy (CAA) is a disease caused by the deposition of amyloid-beta (Aβ) in cerebral blood vessels. It is common not only in the elderly and almost all patients with Alzheimer’s disease (AD) but can also occur independently of other AD-related pathologies. The presence and severity of CAA promote the progression of AD-related cl...
Neurohackademy: Combining Online and Offline Neurological Informatics Education Background Introduction In recent years, human neuroscience has entered an era of big data. Due to initiatives like the Human Connectome Project and the Adolescent Brain Cognitive Development (ABCD) study, scientists have acquired datasets of previously unimaginable sca...
Controlling the Spectral Persistence of a Random Laser Research Background Since their theoretical proposal by Letokhov in the 1960s, Random Lasers (hereinafter referred to as RLs) have gradually become a widely researched field. A significant feature of RLs is that they do not require precisely manufactured optical cavities, which gives them consi...
Special Report: Pound–Drever–Hall Feedforward Technique: Laser Phase Noise Suppression Beyond Feedback Authors: Yu-Xin Chao, Zhen-Xing Hua, Xin-Hui Liang, Zong-Pei Yue, Li You, Meng Khoon Tey Institution: State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing, China Journal: Optica Publication D...
Research Report on Hybrid Integrated Ultra-Narrow Linewidth Self-Injection Locking 780nm Laser Background In modern technology, narrow linewidth lasers play an essential role in various applications, including classical and quantum sensing, ion trap systems, positioning/navigation/timing systems, optical clocks, and microwave frequency synthesizers...
Research on Interferometric Scattering Microscopy and Spatial Coherence Control for Multiparticle Tracking Background Introduction Interferometric Scattering (iSCAT) microscopy has demonstrated unparalleled performance in the field of label-free optical imaging, especially in the detection and imaging of isolated nanoparticles and molecules. Howeve...
Background Introduction Photon integrated circuits (PICs) are significant for achieving high-speed data transmission. However, traditional photon integrated circuits, which only use a single plane or a limited number of stacked planes, are restricted in optical signal routing. Additionally, coupling losses need to be as low as possible for practica...
Observation of Inter-Band Kelly Sidebands in Coupled Ring Comb Microcombs Background Introduction Kelly Sidebands (KSS) are special dispersive waves that appear in mode-locked systems and have been extensively studied in fiber lasers. However, due to the shorter path lengths of integrated photonics microresonators, their generation in integrated mi...
High-Speed High-Power Free-Space Optical Communication: Direct Modulation of Watt-Level Photonic Crystal Surface-Emitting Lasers Background Introduction As a vital light source for optical communication, semiconductor lasers are widely used due to their small size, low cost, long lifespan, and high efficiency. For example, vertical-cavity surface-e...