Serum Neurofilament Light Chain and Cognitive Performance in Women with and without HIV: A Longitudinal Study Over Approximately 8 Years Research Background With the widespread use of highly active antiretroviral therapy (ART), the life expectancy of individuals infected with human immunodeficiency virus (HIV) has significantly increased. However, ...
Homeostasis and Metabolism of Iron and Other Metal Ions in Neurodegenerative Diseases Academic Background Neurodegenerative diseases (such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and Huntington’s disease) are characterized by neuronal death and gradual loss of function, leading to the deterioration of cognitive, ...
Research Background and Problem Introduction Protein O-GlcNAc glycosylation is an important post-translational modification that plays a critical role in cellular metabolic plasticity. Aberrant O-GlcNAc glycosylation levels have been observed in various cancers, including endometrial cancer (EC), a common malignancy in women. However, clinical char...
Cancer Cells Evade Immune Cell-Induced Ferroptosis via Fatty Acid Binding Protein 7 Background Introduction Cancer creates an immunosuppressive environment that hinders immune responses, allowing tumors to grow and resist treatment. The immune system combats this by inducing ferroptosis in tumor cells through CD8+ T cells. Ferroptosis is a type of ...
Mechanism Study on 5-Hydroxytryptamine Regulating Histone Modifications to Drive Liver Metastasis Academic Background Cancer metastasis is one of the leading causes of cancer patient mortality, especially visceral organ metastases such as liver metastasis (liver metastasis). Neuroendocrine tumors (NETs) are a class of highly metastatic tumors, amon...
UC-II® Undenatured Type II Collagen Retention in Functional Food and Beverage Processing Academic Background Collagen is widely used in the food and beverage industry to enhance the nutritional and health value of products. Specifically, undenatured type II collagen (UC-II®) has garnered attention for its potential benefits to joint health. However...
Causal Associations Between Sleep Traits, Sleep Disorders, and Glioblastoma: A Two-Sample Bidirectional Mendelian Randomization Study Academic Background Introduction Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor, accounting for nearly 50% of all primary brain tumors in adults. It primarily originates from astro...
The Effect of Calcium Channel Blocker Nimodipine on Human Spinal Reflex Pathways Academic Background Motor control is one of the essential functions of the nervous system, and spinal reflex pathways play a key role in this process. In animal studies, voltage-sensitive calcium channels (VSCCs) have been identified as critical factors in regulating t...
A Cross-Tissue Transcriptome-Wide Association Study Identifies New Susceptibility Genes for Insomnia Background Insomnia is the second most prevalent psychiatric disorder, affecting nearly one-third of the global population. It not only diminishes quality of life but also increases the risk of cardiovascular diseases, metabolic disorders, mood diso...
Transspinal Stimulation Downregulates Flexion Reflex Pathways During Walking in Healthy Humans Academic Background Human walking is a complex motor process involving the coordinated work of the central and peripheral nervous systems. The spinal cord, as a crucial part of the central nervous system, plays a key role in controlling motor reflexes and...