Research Background Recessive dystrophic epidermolysis bullosa (RDEB) is a rare genetic skin disorder caused by mutations in the COL7A1 gene, leading to the absence or dysfunction of type VII collagen (C7). Type VII collagen is a crucial protein for maintaining skin structural stability, and its deficiency makes patients’ skin extremely fragile, pr...

Predictive Factors for Treatment Responses to Baricitinib in Severe Alopecia Areata: A Retrospective Multivariate Analysis Academic Background Alopecia Areata (AA) is a chronic autoimmune skin disease characterized by non-scarring hair loss. Its pathogenesis involves an abnormal immune attack on hair follicles, leading to hair loss. In recent years...

Clinical Characteristics and Possible Mechanisms of Age Differences in Bullous Pemphigoid (BP) Patients Academic Background Bullous Pemphigoid (BP) is an acquired autoimmune blistering disease that primarily affects elderly patients. However, in recent years, the incidence of BP among younger individuals has also increased, with younger patients of...

Biomarkers Associated with the Progression of Infantile Hemangioma: An Exploratory Study Academic Background Infantile Hemangioma (IH) is one of the most common benign tumors in infancy. Although most IH is not apparent at birth, it gradually manifests within the first month of life and undergoes a proliferative phase over approximately one year, f...

Real-World 52-Week Effectiveness Study of Deucravacitinib in Psoriasis Background Introduction Psoriasis is a chronic inflammatory skin disease with a global prevalence of approximately 1% to 3%. This condition not only affects patients’ quality of life (QoL) but is also often accompanied by comorbidities such as cardiovascular diseases, diabetes, ...

History and Prospects of Nagashima-Type Palmoplantar Keratosis Background Palmoplantar keratoderma (PPK) is a group of hereditary or inflammatory skin disorders characterized by hyperkeratosis of the palms and soles, with diverse clinical manifestations and complex diagnostic criteria. Nagashima-type palmoplantar keratosis (NPPK) is the most common...

Real-world Assessment of Patient Characteristics, Clinical Features, Treatment Patterns, and Outcomes Associated with Erythropoietic Protoporphyria and X-linked Protoporphyria Academic Background Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP) are two rare inherited metabolic disorders. The prevalence of EPP varies across coun...

Characteristics of Suitable Cases for Nemolizumab Treatment Based on Clinical Findings and Cutaneous Adverse Events Academic Background Atopic Dermatitis (AD) is a common chronic inflammatory skin disease, characterized by intense itching that significantly impacts patients’ quality of life. In recent years, treatment methods for AD have advanced, ...

Stochastic Modeling of Single-Cell Gene Expression Adaptation Reveals Non-Genomic Contribution to Tumor Subclone Evolution Academic Background Cancer is a complex disease whose progression is driven by the evolution of cells that are selected through adaptive advantages for growth. Traditionally, cancer evolution research has focused primarily on g...

New Breakthrough in T Cell Receptor (TCR) Specificity Prediction: The Introduction of the SCEPTR Model Academic Background T cell receptors (TCRs) play a crucial role in the immune system by determining the specificity of immune responses through their binding to peptide-MHC complexes (pMHCs). Understanding the interaction between TCRs and specific...