HNRNPR-Mediated UPF3B mRNA Splicing Drives Hepatocellular Carcinoma Metastasis In recent years, hepatocellular carcinoma (HCC) has become one of the leading causes of cancer-related deaths worldwide due to its highly invasive and metastatic nature. The mechanisms underlying HCC metastasis are complex, with abnormal alternative splicing (AS) playing...

High-Performance SERS Detection of Dye Contaminants Using Novel Functionalized Carbon Dots Academic Background Dye molecules play a vital role in daily life, but the environmental pollution caused by their use cannot be ignored. Among them, Malachite Green (MG) is a triphenylmethane dye with potential carcinogenic, teratogenic, and mutagenic effect...

Collecting Duct NCOR1 Regulates Blood Pressure by Controlling Mineralocorticoid Receptor Academic Background Hypertension is one of the major risk factors for cardiovascular and cerebrovascular diseases globally, with complex and not fully elucidated mechanisms. The kidney plays a critical role in blood pressure regulation, particularly in the proc...

Metformin Enhances Plant Immunity by Blocking BIK1-Mediated CPK28 Phosphorylation Academic Background In the context of the increasingly severe global food security issues, controlling crop diseases has become a major challenge in agricultural production. Although traditional chemical pesticides can effectively control diseases, the environmental p...

Metal-Free Production of Natural Blue Colorants: Novel Insights from Anthocyanin-Protein Interactions Academic Background With increasing consumer awareness of health and natural food ingredients, the demand for natural colorants has been on the rise. However, natural blue colorants are scarce, and their production poses significant challenges. Cur...

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...

Melatonin Alleviates High Temperature Exposure-Induced Fetal Growth Restriction via the Gut-Placenta-Fetus Axis Research Background Global climate warming has become a significant threat to human health, particularly affecting pregnant women and fetuses. Studies have shown that high-temperature exposure increases the risk of adverse pregnancy outco...

Achieving Healthy Aging through Gut Microbiota-Directed Dietary Intervention: Focusing on Microbial Biomarkers and Host Mechanisms Academic Background With the intensification of global population aging, preventing age-related diseases and extending healthy life expectancy have become critical issues in global public health. Gut microbiota has been...

The Role of Transcription Factor AoMsn2 in the Hog1 Signaling Pathway in Fungal Growth, Development, and Pathogenicity Background Plant-parasitic nematodes cause significant annual losses to agriculture, while nematode-trapping fungi (NT fungi), due to their ability to capture nematodes by forming specialized trapping structures, have gradually bec...

Exploring the Impacts of Senescence on Implantation and Early Embryonic Development Using Totipotent Cell-Derived Blastoids Academic Background With the increasing trend of delayed childbearing in modern society, reproductive issues among women of advanced maternal age (AMA) have become increasingly prominent. Studies have shown that the implantati...