Inducing Immune Tolerance through Peripheral Clonal Deletion Targeting PD-1 Expressing Cells Background Introduction The establishment of T-cell receptor (TCR) repertoire through thymic negative selection is a key process for achieving self-tolerance and acquired tolerance post-organ transplantation. However, it remains unclear whether the specific...
New Findings on the Detection of Single-Stranded DNA by the Human Immune System: The Role of Schlafen 11 in Innate Immune Response Research Background In the innate immune system, pattern recognition receptors (PRRs) play a crucial role. They initiate an immune response by recognizing pathogen-associated molecular patterns (PAMPs) and damage-associ...
Tumor Immunology Research: The Exhausted State of CD8+ T Cells in Tumors In recent years, immunotherapy has achieved significant progress in the field of tumor treatment. However, tracking the behavior of lymphocytes following antigen signals remains challenging. This study aims to address this issue by developing Antigen Receptor Signaling Reporte...
Tissue-Resident Capacity of Long-Term Surviving KLRG1+ Effector Memory T Cells Background Memory CD8 T cells play a crucial role in the body’s defense against pathogen reinfection. Memory T cells are a heterogeneous group of cells present in various tissues throughout the body, providing essential surveillance and rapid response functions. Memory T...
In the past few decades, with the rapid development of science and technology, human understanding of the immune system has continuously deepened. Among all immune cells, professional phagocytes (such as neutrophils and macrophages) play a crucial role in clearing apoptotic cells, cell debris, and invading pathogens. These cells uptake and engulf f...
Cancer Immunology Lactate-SREBP2 Signaling Axis-Driven Tolerogenic Dendritic Cell Maturation and Its Role in Promoting Cancer Progression Background In cancer, conventional dendritic cells (DCs) are key mediators of anti-tumor immunity. However, cancer has evolved mechanisms that render DCs ineffective in the tumor microenvironment (TME), and these...
Background Introduction In respiratory diseases, the lung is a sensitive organ exposed to the external environment, making it susceptible to pathogens, allergens, and toxic particles. Due to the high morbidity and mortality associated with respiratory diseases (such as asthma), it is crucial to study the mechanisms protecting the cells on the surfa...
Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...
对于一篇关于血吸虫感染早期反应的深入研究，Houlder等人撰写的论文为科学界提供了重要的见解。他们的研究发表于《科学免疫学》(Sci. Immunol.) 2024年7月5日的第9卷，揭示了血吸虫（Schistosoma mansoni...
MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...