Functional Correlation between Myeloid Cells and Membrane Abundance

In the past few decades, with the rapid development of science and technology, human understanding of the immune system has continuously deepened. Among all immune cells, professional phagocytes (such as neutrophils and macrophages) play a crucial role in clearing apoptotic cells, cell debris, and invading pathogens. These cells uptake and engulf f...

A Lactate-SREBP2 Signaling Axis Drives Tolerogenic Dendritic Cell Maturation and Promotes Cancer Progression

Cancer Immunology Lactate-SREBP2 Signaling Axis-Driven Tolerogenic Dendritic Cell Maturation and Its Role in Promoting Cancer Progression Background In cancer, conventional dendritic cells (DCs) are key mediators of anti-tumor immunity. However, cancer has evolved mechanisms that render DCs ineffective in the tumor microenvironment (TME), and these...

Gfi1b Specifies Developmental Potential of Innate Lymphoid Cell Progenitors in the Lungs

Background Introduction In respiratory diseases, the lung is a sensitive organ exposed to the external environment, making it susceptible to pathogens, allergens, and toxic particles. Due to the high morbidity and mortality associated with respiratory diseases (such as asthma), it is crucial to study the mechanisms protecting the cells on the surfa...

Single-Cell Topographical Profiling of the Immune Synapse Reveals a Biomechanical Signature of Cytotoxicity

Single-Cell Topographical Analysis Reveals Biomechanical Characteristics of Cytotoxic T Cells Introduction In recent years, research on how the immune system functions in different mechanochemical environments has shown that immune cells dynamically alter their shape and exert forces on their surroundings to sense physical parameters and activate i...

Characterization of early inflammatory responses and cytokine changes during schistosome infection

对于一篇关于血吸虫感染早期反应的深入研究,Houlder等人撰写的论文为科学界提供了重要的见解。他们的研究发表于《科学免疫学》(Sci. Immunol.) 2024年7月5日的第9卷,揭示了血吸虫(Schistosoma mansoni...

MAIT Cells Monitor Intestinal Dysbiosis and Contribute to Host Protection During Colitis

MAIT Cells Monitor Gut Microbiota Dysbiosis and Protect the Host in Colitis Research Background As research on the relationship between the gut and host health deepens, changes in the gut microbiome are closely related to various human diseases, especially inflammatory bowel disease (IBD). Currently, it is recognized that under homeostatic conditio...

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis

Study of TGF-β1 in Fibrosis Progression: An Exploration of an Antibody Targeting Binding Proteins Research Background Fibrosis is a leading cause of poor prognosis in numerous diseases, such as chronic kidney disease, non-alcoholic steatohepatitis, and idiopathic pulmonary fibrosis. Despite the substantial medical need, directly targeting fibrosis ...

IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells

Review on the Study of IL-12 Promoting Human Follicular Regulatory T Cell Differentiation Research Background Follicular helper T cells (Tfh) play a crucial regulatory role in B cell responses to pathogens and vaccines. When not properly controlled, Tfh cells can lead to the production of antibodies against self-antigens or allergens. Follicular re...

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening

Targeting T Cell Plasticity to Treat Inflammation in the Kidney and Gut: A Study Using Pooled Single-cell CRISPR Screening Background of the Study This paper, co-authored by Leon U.B. Enk and others, was published in the June 14, 2024, issue of “Science Immunology” under the title “Targeting T cell plasticity in kidney and gut inflammation by poole...

Salivary Testosterone Levels and Pain Perception Exhibit Sex-Specific Association in Healthy Adults but Not in Patients with Migraine

The Level of Salivary Testosterone and Pain Perception Show Sex-Specific Associations in Healthy Adults, But Not in Migraine Patients Introduction Understanding the complexity of pain and the role gender plays in pain perception is of significant importance in medical research. Pain is an unpleasant sensory and emotional experience associated with ...