The research team consisting of Guilan Shi, Jody Synowiec, Julie Singh, and Richard Heller published a paper titled “Modification of the tumor microenvironment enhances immunity with plasmid gene therapy” in Cancer Gene Therapy. The background of the study stems from current challenges in the field of tumor immunotherapy, such as tumor cells evadin...

GRIN2A Mutations as a Novel Indicator for Stratifying Beneficiaries of Immune Checkpoint Inhibitors in Various Cancers Background Immune checkpoint inhibitors (ICIs) therapy, which modulates the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death (ligand) 1 (PD-(L)1) pathways, has made revolutionary progress in treating v...

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...

Role of Syndecan Binding Protein (SDCBP) in Regulating Tumor Microenvironment, Tumor Progression, and Anti-PD1 Efficacy in Colorectal Cancer Background In recent years, immunotherapy has brought revolutionary advancements in cancer treatment. However, for colorectal cancer (CRC), anti-programmed cell death 1 (APD1) therapy shows relatively limited ...

A Retrospective Cross-Sectional Observational Study on the Distribution of Coronal Plane Alignment Classifications in Chinese Osteoarthritic and Healthy Populations Research Background Neutral mechanical alignment (MA) of the knee is considered the cornerstone of successful and durable total knee arthroplasty (TKA). However, the existence of “const...

Single-Cell Analysis of Anti-BCMA CAR-T Cell Therapy in Patients with Central Nervous System Autoimmune Diseases Introduction Chimeric Antigen Receptor (CAR) T-cell therapy has shown potential long-term control in treating central nervous system (CNS) autoimmune diseases. This paper investigates the effects of anti-BCMA (B-cell maturation antigen) ...

TH17 Endogenous IL-1β–STAT5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation Academic Background Steroid resistance is a major challenge in managing various inflammatory diseases, including autoimmune neuroinflammation. T helper 17 (TH17) cells are widely believed to be associated with steroid resistance. However, the specific mechani...

Nucleotide Adduct Binding MR1 and Activation of MR1-Restricted T Cells Academic Background MR1T cells, a recently discovered class of T cells, can recognize antigens presented by MHC class I-related molecule MR1 without microbial infection. These cells exhibit both helper and cytotoxic properties in vitro, but the endogenous antigens they recognize...

Inducing and Optimizing VRC01-like Broadly Neutralizing Antibodies in Mouse Models with mRNA-LNP Background Introduction In recent years, the importance of acquiring broadly neutralizing antibodies (bnAbs) has been increasingly recognized in vaccine development, particularly in the field of HIV (Human Immunodeficiency Virus) vaccine research. The H...

Research Progress in Cancer Immunology: Tumor-derived Antigen Signals Induce CD8+ T-cell Exhaustion Localized to the Tumor Site Research Background and Purpose In recent years, immunotherapy has shown great potential in cancer treatment. However, tracking the behavior of immune cells after receiving antigen signals remains a challenge. Within tumor...