Research Background γδ T cells play an important role in the immune system, particularly in protective immunity, homeostasis, and tissue repair. Unlike conventional αβ T cells, which are restricted by major histocompatibility complex (MHC), γδ T cells directly seed peripheral tissues and respond to various microbial stimuli without relying on MHC-p...
Gastrointestinal Infections and Gastrointestinal Bleeding in CAR-T Cell Recipients are Underrated but Severe Adverse Events: A Real-World Study Introduction In recent years, Chimeric Antigen Receptor T-cell (CAR-T) therapy has shown lasting efficacy in treating patients with hematologic malignancies. However, multi-system toxic reactions associated...
Orthogonal Proteogenomic Analysis Identifies Druggable PA2G4-MYC Axis in 3q26 AML Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive malignancy. In particular, the 3q26 chromosomal abnormality subtype of AML has a complex pathogenic mechanism and lacks effective targeted therapies. To address this challenge, Matteo Marchesini and...
Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...
Interactive Mechanisms Between Cancer Cells and Macrophages Facilitate Pancreatic Cancer Cachexia Background Pancreatic cancer is currently the third leading cause of cancer-related death in the United States and is expected to become the second leading cause of cancer death within the next decade. Unfortunately, more than 80% of pancreatic cancer ...
Applying STING Function to BH3-Mimetic Drugs for Treating TP53 Mutant Blood Cancers In the recently published article in Cancer Cell titled “Putting the sting back into BH3-mimetic drugs for TP53-mutant blood cancers,” Sarah T. Diepstraten and colleagues conducted in-depth research to explore how to enhance the efficacy of BH3-mimetic drugs in TP53...
Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...
ARID1A Loss and B Cell Fate and Lymphoma Occurrence Background Introduction This paper investigates the critical role of ARID1A (AT-Rich Interactive Domain 1A) in B cell fate determination and lymphoma occurrence. ARID1A is an important subunit of the BRG1/Brahma-associated factors (BAF) complex, with mutations commonly found in various human malig...
Scientific Report: Study Reveals the Role of SMARCA4 in B Cell Lymphoma Background Introduction The germinal center (GC) plays a crucial role in the maturation and apoptosis of B cells. The GC reaction is a rapid and transient immune response structure that improves the affinity of B cells to specific antigens through somatic mutation and affinity ...
Background Myelodysplastic Syndromes (MDS) are a group of heterogeneous diseases originating from bone marrow hematopoietic stem cells, characterized by reduced blood cell production. Although certain progress in treatment has been made in recent years, allogeneic hematopoietic stem-cell transplantation (HSCT) remains the only potentially curative ...